In the adult mammalian hippocampus, new neurons arise from stem and progenitor cell
division, in a process known as adult neurogenesis. Adult-generated neurons are sensitive …

This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Traumatic brain injury (TBI) is the leading cause of death and disability in individuals below
age 45, and five million Americans live with chronic disability as a result. Mild TBI (mTBI) …

Abstract “Are new neurons added in the adult mammalian brain?”“Do neural stem cells
activate following CNS diseases?”“How can we modulate their activation to promote …

Traumatic brain injury (TBI) promotes neural stem/progenitor cell (NSC) proliferation in an
attempt to initiate innate repair mechanisms. However, all immature neurons in the CNS are …

Hippocampal dentate gyrus is a focus of enhanced neurogenesis and excitability after
traumatic brain injury. Increased neurogenesis has been proposed to aid repair of the …

New neurons are generated in the hippocampal dentate gyrus from early development
through adulthood. Progenitor cells and immature granule cells in the subgranular zone are …

Abstract Purpose of Review Traumatic brain injury (TBI) is a global public health concern,
with limited treatment options available. Despite improving survival rate after TBI, treatment …

Traumatic brain injury (TBI) is one of the leading causes of death among young people, and
is increasingly prevalent in the aging population. Survivors of TBI face a spectrum of …

In the adult brain, self-renewing radial-glia like (RGL) progenitor cells have been shown to
reside in the subventricular zone and the subgranular zone of the hippocampus. A large …