Mucosal-associated invariant T cells: unconventional development and function
L Le Bourhis, L Guerri, M Dusseaux, E Martin… - Trends in …, 2011 - cell.com
Mucosal-associated invariant T (MAIT) cells are a population of T cells that display a semi-
invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major …
invariant T cell receptor (TCR) and are restricted by the evolutionarily conserved major …
An overview on the identification of MAIT cell antigens
L Kjer‐Nielsen, AJ Corbett, Z Chen… - Immunology and cell …, 2018 - Wiley Online Library
Mucosal associated invariant T (MAIT) cells are restricted by the monomorphic MHC class I‐
like molecule, MHC‐related protein‐1 (MR 1). Until 2012, the origin of the MAIT cell antigens …
like molecule, MHC‐related protein‐1 (MR 1). Until 2012, the origin of the MAIT cell antigens …
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the …
(TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the …
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers
Studies on the biology of mucosal-associated invariant T cells (MAIT cells) in mice have
been hampered by a lack of specific reagents. Using MR1-antigen (Ag) tetramers that …
been hampered by a lack of specific reagents. Using MR1-antigen (Ag) tetramers that …
Stepwise development of MAIT cells in mouse and human
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features:
an invariant T cell receptor (TCR) α (iTCRα) chain and restriction by the nonpolymorphic …
an invariant T cell receptor (TCR) α (iTCRα) chain and restriction by the nonpolymorphic …
Invariant Vα19i T cells regulate autoimmune inflammation
JL Croxford, S Miyake, YY Huang, M Shimamura… - Nature …, 2006 - nature.com
T cells expressing an invariant Vα19-Jα33 T cell receptor α-chain (Vα19i TCR) are restricted
by the nonpolymorphic major histocompatibility complex class Ib molecule MR1. Whether …
by the nonpolymorphic major histocompatibility complex class Ib molecule MR1. Whether …
Functional heterogeneity and antimycobacterial effects of mouse mucosal-associated invariant T cells specific for riboflavin metabolites
Mucosal-associated invariant T (MAIT) cells have a semi-invariant TCR Vα-chain, and their
optimal development is dependent upon commensal flora and expression of the …
optimal development is dependent upon commensal flora and expression of the …
Mucosal‐associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis
A Chiba, R Tajima, C Tomi, Y Miyazaki… - Arthritis & …, 2012 - Wiley Online Library
Objective The function of mucosal‐associated invariant T (MAIT) cells remains largely
unknown. We previously reported an immunoregulatory role of MAIT cells in an animal …
unknown. We previously reported an immunoregulatory role of MAIT cells in an animal …
MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells
S Huang, S Gilfillan, S Kim, B Thompson… - The Journal of …, 2008 - rupress.org
Like CD1d-restricted i NKT cells, mucosal-associated invariant T cells (MAITs) are “innate” T
cells that express a canonical TCRα chain, have a memory phenotype, and rapidly secrete …
cells that express a canonical TCRα chain, have a memory phenotype, and rapidly secrete …
CD1d-and MR1-restricted invariant T cells: of mice and men
CD1d-restricted natural killer T cells and MR1-restricted mucosal associated invariant T
(MAIT) cells constitute two subsets of unconventional T cells that are phylogenetically …
(MAIT) cells constitute two subsets of unconventional T cells that are phylogenetically …