Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution
Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
Correlation of BUB1 and BUB1B with the development and prognosis of endometrial cancer
H Zhang, Y Li, H Lu - Scientific Reports, 2024 - nature.com
This study aimed to evaluate the expression and clinical significance of budding uninhibited
by benzimidazole 1 (BUB1) and BUB1 mitotic checkpoint serine/threonine kinase B …
by benzimidazole 1 (BUB1) and BUB1 mitotic checkpoint serine/threonine kinase B …
Arabidopsis Cell Division Cycle 20.1 Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation
Cell division requires proper spindle assembly; a surveillance pathway, the spindle
assembly checkpoint (SAC), monitors whether the spindle is normal and correctly attached …
assembly checkpoint (SAC), monitors whether the spindle is normal and correctly attached …
[HTML][HTML] Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer
M Calheiros-Lobo, JPN Silva, B Pinto, L Monteiro… - Pharmaceutics, 2024 - mdpi.com
Head and neck cancer (HNC), the sixth most common cancer worldwide, is increasing in
incidence, with oral squamous cell carcinoma (OSCC) as the predominant subtype. OSCC …
incidence, with oral squamous cell carcinoma (OSCC) as the predominant subtype. OSCC …
OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
VE Marotta, D Sabat-Pośpiech, AB Fielding… - EMBO …, 2025 - embopress.org
Cancer cells often display centrosome amplification, requiring the kinesin KIFC1/HSET for
centrosome clustering to prevent multipolar spindles and cell death. In parallel siRNA …
centrosome clustering to prevent multipolar spindles and cell death. In parallel siRNA …
Oral pathology in Portuguese dogs: an eight-year biopsy-based retrospective study
L Delgado, P Brilhante-Simões… - Journal of Veterinary …, 2023 - journals.sagepub.com
The oral cavity of the dog can be the site of several types of pathology including both benign
and malignant lesions. The aim of this study was to analyze the frequency and clinical …
and malignant lesions. The aim of this study was to analyze the frequency and clinical …
[HTML][HTML] Tank binding kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells
M Maan, NJ Agrawal, J Padmanabhan… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Error-free progression through mitosis is critical for proper cell division and accurate
distribution of the genetic material. The anaphase-promoting complex/cyclosome (APC/C) …
distribution of the genetic material. The anaphase-promoting complex/cyclosome (APC/C) …
Previous infection with SARS‐CoV‐2 impacts embryo morphokinetics but not clinical outcomes in a time‐lapse imaging system
DPAF Braga, AS Setti, A Iaconelli Jr… - Molecular …, 2023 - Wiley Online Library
The goal for the present study was to investigate whether previous infection with severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) may compromise embryo …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) may compromise embryo …
The anaphase‐promoting complex: A key mitotic regulator associated with somatic mutations occurring in cancer
PG Melloy - Genes, Chromosomes and Cancer, 2020 - Wiley Online Library
The anaphase‐promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that helps
control chromosome separation and exit from mitosis in many different kinds of organisms …
control chromosome separation and exit from mitosis in many different kinds of organisms …