The molecular determinants of microglial developmental dynamics

L Barry-Carroll, D Gomez-Nicola - Nature Reviews Neuroscience, 2024 - nature.com
Microglia constitute the largest population of parenchymal macrophages in the brain and are
considered a unique subset of central nervous system glial cells owing to their extra …

Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer

Z Shah, L Tian, Z Li, L **, J Zhang, Z Li, T Barr, H Tang… - Cell Stem Cell, 2024 - cell.com
Due to the limitations of autologous chimeric antigen receptor (CAR)-T cells, alternative
sources of cellular immunotherapy, including CAR macrophages, are emerging for solid …

[HTML][HTML] Modelling post-implantation human development to yolk sac blood emergence

J Hislop, Q Song, K Keshavarz F, A Alavi… - Nature, 2024 - nature.com
Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …

[HTML][HTML] The pluripotent path to immunotherapy

MP Diop, SJC van der Stegen - Experimental Hematology, 2024 - Elsevier
Adoptive cell therapy (ACT) enhances the patient's own immune cells' ability to identify and
eliminate cancer cells. Several immune cell types are currently being applied in autologous …

Elevated shear stress modulates heterogenous cellular subpopulations to induce vascular remodeling

KS Fischer, D Henn, ET Zhao, D Sivaraj… - … Engineering Part A, 2024 - liebertpub.com
Rationale: Elevated shear stress (ESS) induces vascular remodeling in veins exposed to
arterial blood flow, which can lead to arteriovenous (AV) fistula failure. The molecular …

Building a human lung from pluripotent stem cells to model respiratory viral infections

DL Turner, S Amoozadeh, H Baric, E Stanley… - Respiratory …, 2024 - Springer
To protect against the constant threat of inhaled pathogens, the lung is equipped with
cellular defenders. In coordination with resident and recruited immune cells, this defence is …

[PDF][PDF] Unraveling the dynamics of myometrial remodeling: insights from single-cell and spatial transcriptomics in term pregnancy

YL Pai, KJ Lavine, JM Amrute - Physiological genomics, 2024 - journals.physiology.org
Pregnancy is a remarkable journey marked by intricate physiological changes and
adaptations 6 within the maternal body to support fetal growth and development. Among …

Insights into the role of immune cells in development and regeneration

F Ginhoux, P Martin - Development, 2022 - journals.biologists.com
Inflammatory cells are primarily considered as important for resolving infections; indeed,
whenever a tissue is infected, a rapid and robust inflammatory response is triggered to clear …