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The molecular determinants of microglial developmental dynamics
L Barry-Carroll, D Gomez-Nicola - Nature Reviews Neuroscience, 2024 - nature.com
Microglia constitute the largest population of parenchymal macrophages in the brain and are
considered a unique subset of central nervous system glial cells owing to their extra …
considered a unique subset of central nervous system glial cells owing to their extra …
Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer
Due to the limitations of autologous chimeric antigen receptor (CAR)-T cells, alternative
sources of cellular immunotherapy, including CAR macrophages, are emerging for solid …
sources of cellular immunotherapy, including CAR macrophages, are emerging for solid …
[HTML][HTML] Modelling post-implantation human development to yolk sac blood emergence
Implantation of the human embryo begins a critical developmental stage that comprises
profound events including axis formation, gastrulation and the emergence of haematopoietic …
profound events including axis formation, gastrulation and the emergence of haematopoietic …
[HTML][HTML] The pluripotent path to immunotherapy
MP Diop, SJC van der Stegen - Experimental Hematology, 2024 - Elsevier
Adoptive cell therapy (ACT) enhances the patient's own immune cells' ability to identify and
eliminate cancer cells. Several immune cell types are currently being applied in autologous …
eliminate cancer cells. Several immune cell types are currently being applied in autologous …
Elevated shear stress modulates heterogenous cellular subpopulations to induce vascular remodeling
Rationale: Elevated shear stress (ESS) induces vascular remodeling in veins exposed to
arterial blood flow, which can lead to arteriovenous (AV) fistula failure. The molecular …
arterial blood flow, which can lead to arteriovenous (AV) fistula failure. The molecular …
Building a human lung from pluripotent stem cells to model respiratory viral infections
DL Turner, S Amoozadeh, H Baric, E Stanley… - Respiratory …, 2024 - Springer
To protect against the constant threat of inhaled pathogens, the lung is equipped with
cellular defenders. In coordination with resident and recruited immune cells, this defence is …
cellular defenders. In coordination with resident and recruited immune cells, this defence is …
[PDF][PDF] Unraveling the dynamics of myometrial remodeling: insights from single-cell and spatial transcriptomics in term pregnancy
Pregnancy is a remarkable journey marked by intricate physiological changes and
adaptations 6 within the maternal body to support fetal growth and development. Among …
adaptations 6 within the maternal body to support fetal growth and development. Among …
Insights into the role of immune cells in development and regeneration
Inflammatory cells are primarily considered as important for resolving infections; indeed,
whenever a tissue is infected, a rapid and robust inflammatory response is triggered to clear …
whenever a tissue is infected, a rapid and robust inflammatory response is triggered to clear …