Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

Small-molecule fluorescent probes are attractive and versatile materials for studying
biological systems.(1-6) They can be easily loaded into cells and rapidly detect biological …

Inside cells, complex metabolic reactions are distributed across the modular compartments
of organelles,. Reactions in organelles have been recapitulated in vitro by reconstituting …

The detailed organization of cellular membranes remains rather elusive. Based on large-
scale molecular dynamics simulations, we provide a high-resolution view of the lipid …

Abstract Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), a component of
Gram-negative bacteria to induce production of pro-inflammatory mediators aiming at …

Proper membrane physiology requires maintenance of biophysical properties, which must
be buffered from external perturbations. While homeostatic adaptation of membrane fluidity …

Cell membranes display a tremendous complexity of lipids and proteins designed to perform
the functions cells require. To coordinate these functions, the membrane is able to laterally …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …