[HTML][HTML] The evolution of seasonal influenza viruses
VN Petrova, CA Russell - Nature Reviews Microbiology, 2018 - nature.com
Despite decades of surveillance and pharmaceutical and non-pharmaceutical interventions,
seasonal influenza viruses continue to cause epidemics around the world each year. The …
seasonal influenza viruses continue to cause epidemics around the world each year. The …
Immune imprinting and next-generation coronavirus vaccines
Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains
SJ Zost, K Parkhouse, ME Gumina… - Proceedings of the …, 2017 - National Acad Sciences
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that
abrogate binding of human antibodies. During the 2014–2015 influenza season, clade 3C …
abrogate binding of human antibodies. During the 2014–2015 influenza season, clade 3C …
Broadly neutralizing antibodies target a haemagglutinin anchor epitope
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus
have the potential to provide near universal protection against influenza virus infection …
have the potential to provide near universal protection against influenza virus infection …
Co-evolution of immunity and seasonal influenza viruses
Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …
escape host immunity. The viral constraints and host immune responses that limit and drive …
[HTML][HTML] Antigenic drift: understanding COVID-19
JW Yewdell - Immunity, 2021 - cell.com
Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral
proteins selected by host adaptive immune systems as the virus circulates in a population …
proteins selected by host adaptive immune systems as the virus circulates in a population …
Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we
collected 201 serum samples from persons with a single infection or multiple vaccine …
collected 201 serum samples from persons with a single infection or multiple vaccine …
From original antigenic sin to the universal influenza virus vaccine
Antibody responses are essential for protection against influenza virus infection. Humans
are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that …
are exposed to a multitude of influenza viruses throughout their lifetime and it is clear that …
Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans
Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a
result, preexisting influenza-specific memory B cells can dominate the response after …
result, preexisting influenza-specific memory B cells can dominate the response after …
Does repeated influenza vaccination attenuate effectiveness? A systematic review and meta-analysis
E Jones-Gray, EJ Robinson, AJ Kucharski… - The Lancet …, 2023 - thelancet.com
Background Influenza vaccines require annual readministration; however, several reports
have suggested that repeated vaccination might attenuate the vaccine's effectiveness. We …
have suggested that repeated vaccination might attenuate the vaccine's effectiveness. We …