Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose
significant challenges to the treating physician. Although an evidence‐based practice …

Eosinophilic inflammation is a feature of allergic asthma. Despite mounting evidence
showing that chromatin filaments released from neutrophils mediate various diseases, the …

Preclinical research has facilitated the discovery of valuable drugs for the symptomatic
treatment of epilepsy. Yet, despite these therapies, seizures are not adequately controlled in …

Over-inhibition is thought to be one of the underlying causes of the cognitive deficits in
Ts65Dn mice, the most widely used model of Down syndrome. We found a direct link …

Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

This review discusses the various aspects of epilepsy in Down syndrome (DS) from the
perspective of paediatric neurology. DS is the most common genetic cause of mental …

Infantile spasms syndrome (ISS) is a catastrophic pediatric epilepsy with motor spasms,
persistent seizures, mental retardation, and in some cases, autism. One of its monogenic …

Epileptic encephalopathies are a group of diseases in which epileptic activity itself
contributes to severe cognitive and behavioral impairments above and beyond what might …

Infantile spasms are characterized by age-specific expression of epileptic spasms and
hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or …