This paper overviews the application of multivariate curve resolution (optimized by
alternating least squares) to spectroscopic data acquired by monitoring chemical reactions …

Real-time analytical tools to monitor bioprocess and fermentation in biological and food
applications are becoming increasingly important. Traditional laboratory-based analyses …

Determination of affinities and binding sites involved in protein–ligand interactions is
essential for understanding molecular mechanisms in biological systems. Here we combine …

Small‐angle X‐ray scattering (SAXS) is an established technique for structural analysis of
biological macromolecules in solution. During the last decade, inline chromatography …

The deposition of aggregates of human islet amyloid peptide (hIAPP) has been correlated
with the death of insulin-producing beta (β) cells in type II diabetes mellitus. The actual …

The modern wine industry needs tools for process control and quality assessment in order to
better manage fermentation or bottling processes. During wine fermentation it is important to …

Noncanonical four-stranded DNA structures, including G-quadruplexes and i-motifs, have
been discovered in the cell and are implicated in a variety of genomic regulatory functions …

To clarify the pH-dependent conformational transitions of proteins, we propose an approach
in which structural changes monitored by heteronuclear sequential quantum correlation …

Spectroscopic techniques offer the potential to simplify and reduce analytical times for a
range of grape and wine analytes. It is this aspect, together with the ability to simultaneously …

Proteins in either a native or denatured conformation often aggregate at an isoelectric point
(pI), a phenomenon known as pI precipitation. However, only a few studies have addressed …