Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane
vesicles, with distinct biogenesis routes, biophysical properties and different functions both …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Misfolded protein aggregates represent a continuum with overlap** features in
neurodegenerative diseases, but differences in protein components and affected brain …

Abstract In variant Creutzfeldt–Jakob disease, prions (PrPSc) enter the body with
contaminated foodstuffs and can spread from the intestinal entry site to the central nervous …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Complement is part of the innate immune defence and not only recognizes microbes but
also unwanted host molecules to enhance phagocytosis and clearance. This process of …

A shared neuropathological feature of idiopathic Parkinson's disease, dementia with Lewy
bodies, and multiple system atrophy is the development of intracellular aggregates of α …

Despite the importance of the aberrant polymerization of Aβ in the early pathogenic cascade
of Alzheimer's disease, little is known about the induction of Aβ aggregation in vivo. Here we …

The prion (infectious protein) concept has evolved with the discovery of new self-
propagating protein states in organisms as diverse as mammals and fungi. The infectious …

Dendritic cells (DC) are the professional antigen-presenting cells of the immune system. In
their quiescent and mature form, the presentation of self‐antigens by DC leads to tolerance; …