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Functional architecture of the retina: development and disease
Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …
that is organized into cell layers with microcircuits working in parallel and together to encode …
Branching out: mechanisms of dendritic arborization
YN Jan, LY Jan - Nature Reviews Neuroscience, 2010 - nature.com
Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …
implications in determining what signals a neuron receives and how these signals are …
[HTML][HTML] Spatial and temporal map** of de novo mutations in schizophrenia to a fetal prefrontal cortical network
Genes disrupted in schizophrenia may be revealed by de novo mutations in affected
persons from otherwise healthy families. Furthermore, during normal brain development …
persons from otherwise healthy families. Furthermore, during normal brain development …
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
LATS (large tumor suppressor) or warts is a Ser/Thr kinase that belongs to the Ndr/LATS
subfamily of AGC (protein kinase A/PKG/PKC) kinases. It is a tumor suppressor gene …
subfamily of AGC (protein kinase A/PKG/PKC) kinases. It is a tumor suppressor gene …
Hippo signaling in organ size control
D Pan - Genes & development, 2007 - genesdev.cshlp.org
The control of organ (or organism) size is a fundamental aspect of life that has long captured
human imagination. What makes an elephant grow a million times larger than a mouse …
human imagination. What makes an elephant grow a million times larger than a mouse …
Dendrite self-avoidance is controlled by Dscam
BJ Matthews, ME Kim, JJ Flanagan, D Hattori… - Cell, 2007 - cell.com
Dendrites distinguish between sister branches and those of other cells. Self-recognition can
often lead to repulsion, a process termed" self-avoidance." Here we demonstrate that …
often lead to repulsion, a process termed" self-avoidance." Here we demonstrate that …
Presynaptic Ube3a E3 ligase promotes synapse elimination through down-regulation of BMP signaling
Inactivation of the ubiquitin ligase Ube3a causes the developmental disorder Angelman
syndrome, whereas increased Ube3a dosage is associated with autism spectrum disorders …
syndrome, whereas increased Ube3a dosage is associated with autism spectrum disorders …
NDR kinases regulate essential cell processes from yeast to humans
A Hergovich, MR Stegert, D Schmitz… - … reviews Molecular cell …, 2006 - nature.com
Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components
of pathways that control important cellular processes, such as morphological changes …
of pathways that control important cellular processes, such as morphological changes …
MST kinases in development and disease
BJ Thompson, E Sahai - Journal of Cell Biology, 2015 - rupress.org
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …
Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization
A neuron's dendrites typically do not cross one another. This intrinsic self-avoidance
mechanism ensures unambiguous processing of sensory or synaptic inputs. Moreover …
mechanism ensures unambiguous processing of sensory or synaptic inputs. Moreover …