Functional architecture of the retina: development and disease

M Hoon, H Okawa, L Della Santina… - Progress in retinal and eye …, 2014 - Elsevier
Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

Branching out: mechanisms of dendritic arborization

YN Jan, LY Jan - Nature Reviews Neuroscience, 2010 - nature.com
Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …

[HTML][HTML] Spatial and temporal map** of de novo mutations in schizophrenia to a fetal prefrontal cortical network

S Gulsuner, T Walsh, AC Watts, MK Lee, AM Thornton… - Cell, 2013 - cell.com
Genes disrupted in schizophrenia may be revealed by de novo mutations in affected
persons from otherwise healthy families. Furthermore, during normal brain development …

Tumor suppressor LATS1 is a negative regulator of oncogene YAP

Y Hao, A Chun, K Cheung, B Rashidi, X Yang - Journal of Biological …, 2008 - jbc.org
LATS (large tumor suppressor) or warts is a Ser/Thr kinase that belongs to the Ndr/LATS
subfamily of AGC (protein kinase A/PKG/PKC) kinases. It is a tumor suppressor gene …

Hippo signaling in organ size control

D Pan - Genes & development, 2007 - genesdev.cshlp.org
The control of organ (or organism) size is a fundamental aspect of life that has long captured
human imagination. What makes an elephant grow a million times larger than a mouse …

Dendrite self-avoidance is controlled by Dscam

BJ Matthews, ME Kim, JJ Flanagan, D Hattori… - Cell, 2007 - cell.com
Dendrites distinguish between sister branches and those of other cells. Self-recognition can
often lead to repulsion, a process termed" self-avoidance." Here we demonstrate that …

Presynaptic Ube3a E3 ligase promotes synapse elimination through down-regulation of BMP signaling

K Furusawa, K Ishii, M Tsuji, N Tokumitsu, E Hasegawa… - Science, 2023 - science.org
Inactivation of the ubiquitin ligase Ube3a causes the developmental disorder Angelman
syndrome, whereas increased Ube3a dosage is associated with autism spectrum disorders …

NDR kinases regulate essential cell processes from yeast to humans

A Hergovich, MR Stegert, D Schmitz… - … reviews Molecular cell …, 2006 - nature.com
Members of the NDR (nuclear Dbf2-related) protein-kinase family are essential components
of pathways that control important cellular processes, such as morphological changes …

MST kinases in development and disease

BJ Thompson, E Sahai - Journal of Cell Biology, 2015 - rupress.org
The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization

P Soba, S Zhu, K Emoto, S Younger, SJ Yang, HH Yu… - Neuron, 2007 - cell.com
A neuron's dendrites typically do not cross one another. This intrinsic self-avoidance
mechanism ensures unambiguous processing of sensory or synaptic inputs. Moreover …