The search for noise-induced cochlear synaptopathy in humans: Mission impossible?

N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

Occupational noise: auditory and non-auditory consequences

A Sheppard, M Ralli, A Gilardi, R Salvi - International journal of …, 2020 - mdpi.com
Occupational noise exposure accounts for approximately 16% of all disabling hearing
losses, but the true value and societal costs may be grossly underestimated because current …

Hidden hearing loss? No effect of common recreational noise exposure on cochlear nerve response amplitude in humans

SK Grinn, KB Wiseman, JA Baker… - Frontiers in …, 2017 - frontiersin.org
This study tested hypothesized relationships between noise exposure and auditory deficits.
Both retrospective assessment of potential associations between noise exposure history and …

Hidden hearing loss: a disorder with multiple etiologies and mechanisms

DC Kohrman, G Wan… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to
affect auditory neural processing and hearing acuity in subjects with normal audiometric …

[HTML][HTML] Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure

H Guest, KJ Munro, G Prendergast, RE Millman… - Hearing research, 2018 - Elsevier
In rodents, noise exposure can destroy synapses between inner hair cells and auditory
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced …

Middle ear muscle reflex and word recognition in “normal-hearing” adults: evidence for cochlear synaptopathy?

AM Mepani, SA Kirk, KE Hancock, K Bennett… - Ear and …, 2020 - journals.lww.com
Objectives: Permanent threshold elevation after noise exposure, ototoxic drugs, or aging is
caused by loss of sensory cells; however, animal studies show that hair cell loss is often …

'Normal'hearing thresholds and fundamental auditory grou** processes predict difficulties with speech-in-noise perception

E Holmes, TD Griffiths - Scientific reports, 2019 - nature.com
Understanding speech when background noise is present is a critical everyday task that
varies widely among people. A key challenge is to understand why some people struggle …

Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects

KJ Grant, AM Mepani, P Wu… - Journal of …, 2020 - journals.physiology.org
Hearing loss caused by noise exposure, ototoxic drugs, or aging results from the loss of
sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss …

Effects of lifetime noise exposure on the middle-age human auditory brainstem response, tinnitus and speech-in-noise intelligibility

JT Valderrama, EF Beach, I Yeend, M Sharma… - Hearing research, 2018 - Elsevier
Recent animal studies have shown that the synapses between inner hair cells and the
dendrites of the spiral ganglion cells they innervate are the elements in the cochlea most …

Effects of noise exposure on auditory brainstem response and speech-in-noise tasks: A review of the literature

CG Le Prell - International journal of audiology, 2019 - Taylor & Francis
Objective: Short-term noise exposure that induces transient changes in thresholds has
induced permanent cochlear synaptopathy in multiple species. Here, the literature was …