Novel approaches and current challenges with targeting the endocannabinoid system
Introduction The pathophysiological relevance of the endocannabinoid system has been
widely demonstrated in a variety of diseases including cancer, neurological disorders, and …
widely demonstrated in a variety of diseases including cancer, neurological disorders, and …
Δ9-cis-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology
The cis-stereoisomers of Δ9-THC [(−)-3 and (+)-3] were identified and quantified in a series
of low-THC-containing varieties of Cannabis sativa registered in Europe as fiber hemp and …
of low-THC-containing varieties of Cannabis sativa registered in Europe as fiber hemp and …
Design, synthesis, and biological activity of new CB2 receptor ligands: From orthosteric and allosteric modulators to dualsteric/bitopic ligands
The design of dualsteric/bitopic agents as single chemical entities able to simultaneously
interact with both the orthosteric and an allosteric binding site represents a novel approach …
interact with both the orthosteric and an allosteric binding site represents a novel approach …
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty …
Cannabinoid type 2 receptor (CB2R), belonging to the endocannabinoid system, is
overexpressed in pathologies characterized by inflammation, and its activation counteracts …
overexpressed in pathologies characterized by inflammation, and its activation counteracts …
Advances in the discovery of fatty acid amide hydrolase inhibitors: what does the future hold?
Introduction Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme, that
inactivates endogenous signaling lipids of the fatty acid amide family, including the …
inactivates endogenous signaling lipids of the fatty acid amide family, including the …
The cannabinoid CB2 receptor positive allosteric modulator EC21a exhibits complicated pharmacology in vitro
Schizophrenia is a complex disease involving the dysregulation of numerous brain circuits
and patients exhibit positive symptoms (hallucinations, delusions), negative symptoms …
and patients exhibit positive symptoms (hallucinations, delusions), negative symptoms …
Novel Orthosteric/Allosteric Ligands of Cannabinoid Receptors: An Unexpected Pharmacological Profile
The design of dualsteric/bitopic receptor ligands as compounds capable of simultaneously
interacting with both the orthosteric and an allosteric binding site has gained importance to …
interacting with both the orthosteric and an allosteric binding site has gained importance to …
The endocannabinoid system dual-target ligand N-cycloheptyl-1, 2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease …
Multiple sclerosis is a chronic inflammatory demyelinating disorder of the central nervous
system that eventually leads to progressive neurodegeneration and disability. Recent …
system that eventually leads to progressive neurodegeneration and disability. Recent …
Design, synthesis, and evaluation of anticonvulsant activities of new triazolopyrimidine derivatives
M Song, W Zhao, Y Zhu, W Liu, X Deng… - Frontiers in …, 2022 - frontiersin.org
Epilepsy, a severe brain disease affecting a large population, is treated mainly by
antiepileptic drugs (AEDs). However, toxicity, intolerance, and low efficiency of the available …
antiepileptic drugs (AEDs). However, toxicity, intolerance, and low efficiency of the available …
Interplay Between Endocannabinoid System and Neurodegeneration: Focus on Polypharmacology
Pharmacological treatment of complex pathologies, such as neurodegenerative diseases
still represents a major challenge, due to the networked pathways involved in their onset …
still represents a major challenge, due to the networked pathways involved in their onset …