Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core
surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as …

The past two decades of angiogenesis research have identified a wealth of pro-and
antiangiogenic signals originating from the tissue environment, which control blood vessel …

Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of
connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular …

Mutations in the gene for fibrillin-1 (FBN1) have been shown to cause Marfan syndrome, an
autosomal dominant disorder of connective tissue characterised by pleiotropic …

Advanced stage papillary serous tumors of the ovary are responsible for the majority of
ovarian cancer deaths, yet the molecular determinants modulating patient survival are …

Fibrillins are the major glycoprotein components of microfibrils that form a template for
tropoelastin during elastic fibrillogenesis. We have examined cell adhesion to assembled …

Elastin fibers are predominantly composed of the secreted monomer tropoelastin. This
protein assembly confers elasticity to all vertebrate elastic tissues including arteries, lung …

Since the cancer stem cell concept has been widely accepted, several strategies have been
proposed to attack cancer stem cells (CSC). Accordingly, stem cell markers are now …

The interactions of the dermatan sulfate proteoglycans biglycan and decorin have been
investigated with the elastic fiber components, tropoelastin, fibrillin-containing microfibrils …

It is increasingly evident that the cytoskeleton of living cells plays important roles in
mechanical and biological functions of the cells. Here we focus on the contribution of …