[HTML][HTML] Approved HIV reverse transcriptase inhibitors in the past decade
G Li, Y Wang, E De Clercq - Acta Pharmaceutica Sinica B, 2022 - Elsevier
HIV reverse transcriptase (RT) inhibitors are the important components of highly active
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …
Advances in microbicide vaginal rings
Vaginal ring devices capable of providing sustained/controlled release of incorporated
actives are already marketed for steroidal contraception and estrogen replacement therapy …
actives are already marketed for steroidal contraception and estrogen replacement therapy …
Greater dapivirine release from the dapivirine vaginal ring is correlated with lower risk of HIV‐1 acquisition: a secondary analysis from a randomized, placebo …
Introduction A vaginal ring containing 25 mg of the antiretroviral dapivirine has
demonstrated efficacy in reducing women's risk of sexually acquiring HIV‐1; however …
demonstrated efficacy in reducing women's risk of sexually acquiring HIV‐1; however …
Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir
TJ Johnson, KM Gupta, J Fabian, TH Albright… - European Journal of …, 2010 - Elsevier
Dual segment polyurethane intravaginal rings (IVRs) were fabricated to enable sustained
release of antiretroviral agents dapivirine and tenofovir to prevent the male to female sexual …
release of antiretroviral agents dapivirine and tenofovir to prevent the male to female sexual …
Microbicide vaginal rings: Technological challenges and clinical development
RK Malcolm, PJ Boyd, CF McCoy, DJ Murphy - Advanced drug delivery …, 2016 - Elsevier
Vaginal rings (VRs) are flexible, torus-shaped, polymeric devices designed to sustain
delivery of pharmaceutical drugs to the vagina for clinical benefit. Following first report in a …
delivery of pharmaceutical drugs to the vagina for clinical benefit. Following first report in a …
Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy
The HIV/AIDS pandemic and its impact on women prompt the investigation of prevention
strategies to interrupt sexual transmission of HIV. Long-acting drug delivery systems that …
strategies to interrupt sexual transmission of HIV. Long-acting drug delivery systems that …
Microbicides: topical prevention against HIV
RJ Shattock, Z Rosenberg - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Microbicides represent a potential intervention strategy for preventing HIV transmission.
Vaginal microbicides would meet the need for a discreet method that women could use to …
Vaginal microbicides would meet the need for a discreet method that women could use to …
Development and characterization of a vaginal film containing dapivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), for prevention of HIV-1 sexual …
Dapivirine, a non-nucleoside reverse transcriptase inhibitor, is a potent and promising anti-
HIV molecule. It is currently being investigated for use as a vaginal microbicide in two …
HIV molecule. It is currently being investigated for use as a vaginal microbicide in two …
Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies
AR Thurman, MR Clark, JA Hurlburt… - International journal of …, 2013 - Taylor & Francis
There is a renewed interest in delivering pharmaceutical products via intravaginal rings
(IVRs). IVRs are flexible torus-shaped drug delivery systems that can be easily inserted and …
(IVRs). IVRs are flexible torus-shaped drug delivery systems that can be easily inserted and …
Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: From past failures to future hopes
Infection with human immunodeficiency virus (HIV) remains a global public health concern
and is particularly serious in low-and middle-income countries. Widespread sexual violence …
and is particularly serious in low-and middle-income countries. Widespread sexual violence …