T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome
The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects,
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
amplifies and coordinates cellular immune responses to epitopes derived from cell surface …
Gene map of the extended human MHC
The major histocompatibility complex (MHC) is the most important region in the vertebrate
genome with respect to infection and autoimmunity, and is crucial in adaptive and innate …
genome with respect to infection and autoimmunity, and is crucial in adaptive and innate …
Higher-order inter-chromosomal hubs shape 3D genome organization in the nucleus
Eukaryotic genomes are packaged into a 3-dimensional structure in the nucleus. Current
methods for studying genome-wide structure are based on proximity ligation. However, this …
methods for studying genome-wide structure are based on proximity ligation. However, this …
Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium - Nature, 2004 - nature.com
The sequence of the human genome encodes the genetic instructions for human
physiology, as well as rich information about human evolution. In 2001, the International …
physiology, as well as rich information about human evolution. In 2001, the International …
The DNA sequence of the human X chromosome
MT Ross, DV Grafham, AJ Coffey, S Scherer, K McLay… - Nature, 2005 - nature.com
The human X chromosome has a unique biology that was shaped by its evolution as the sex
chromosome shared by males and females. We have determined 99.3% of the euchromatic …
chromosome shared by males and females. We have determined 99.3% of the euchromatic …
Genetics of Parkinson's disease
CM Lill - Molecular and cellular probes, 2016 - Elsevier
Almost two decades after the identification of SNCA as the first causative gene in
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a …
Parkinson's disease (PD) and the subsequent understanding that genetic factors play a …
Modifications and functional genomics of human transfer RNA
T Pan - Cell research, 2018 - nature.com
Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the
most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively …
most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively …
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
RS Mitchell, BF Beitzel, ARW Schroder, P Shinn… - PLoS …, 2004 - journals.plos.org
The completion of the human genome sequence has made possible genome-wide studies
of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences …
of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences …
The imgt/hla database
It is 14 years since the IMGT/HLA database was first released, providing the HLA community
with a searchable repository of highly curated HLA sequences. The HLA complex is located …
with a searchable repository of highly curated HLA sequences. The HLA complex is located …
The HLA region and autoimmune disease: associations and mechanisms of action
MJ Simmonds, SCL Gough - Current genomics, 2007 - ingentaconnect.com
The HLA region encodes several molecules that play key roles in the immune system.
Strong association between the HLA region and autoimmune disease (AID) has been …
Strong association between the HLA region and autoimmune disease (AID) has been …