Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Abstract Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic
hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has …

Elderly surgical patients frequently experience postoperative delirium (POD) and the
subsequent development of postoperative cognitive dysfunction (POCD). Clinical features …

The cornea serves as an important barrier structure to the eyeball and is vulnerable to
injuries, which may lead to scarring and blindness if not treated promptly. To explore an …

Traumatic brain injury (TBI) is a major cause of injury-related mortality and morbidity in the
USA and around the world. The survivors may suffer from cognitive and memory deficits …

Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue
regeneration therapies. However, the MSC availability in most tissues is limited which …

Spinal cord injury (SCI) can lead to permanent and severe functional impairment below the
lesion level and is still one of the most challenging clinical problems. The treatment of SCI …

The Insulin-like Growth Factor I (IGF-1) signalling pathway is essential for cell growth and
facilitates tumourogenic processes. We recently reported that IGF-1 induces a transcriptional …

The aim of this study is to fabricate and test a 3D-printed PCL scaffold incorporating IGF-1-
releasing PLGA nanoparticles for cartilage tissue engineering. IGF-1 loaded PLGA …

Cellular therapies offer novel opportunities for the treatment of type 2 diabetes mellitus
(T2DM). The present study evaluated the long-term efficacy and safety of infusion of …