The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

Neutrophils are essential for killing bacteria and other microorganisms, and they also have a
significant role in regulating the inflammatory response. Stimulated neutrophils activate their …

Inflammatory bowel disease (IBD) is a debilitating disorder involving inflammation of the
gastrointestinal tract. The incidence of IBD is increasing worldwide. Immunological …

The transcription factor NF-κB plays a major role in coordinating innate and adaptative
immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that …

Exposure of cells to sublethal oxidative stress results in the modulation of various signaling
pathways. Oxidants can activate and inactivate transcription factors, membrane channels …

抄録 There is considerable interest in the role that mammalian heme peroxidase enzymes,
primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide …

Peroxiredoxin 2 is a member of the mammalian peroxiredoxin family of thiol proteins that is
important in antioxidant defense and redox signaling. We have examined its reactivity with …

Sulfur-containing amino acids such as cysteine and methionine are particularly vulnerable
to oxidation. Oxidation of cysteine and methionine in their free amino acid form renders them …

Cysteine and methionine residues are the amino acids most sensitive to oxidation by
reactive oxygen species. However, in contrast to other amino acids, certain cysteine and …

Redox reactions are of high fundamental and practical interest since they are involved in
both normal physiology and the pathogenesis of various diseases. However, this area of …