Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment
A Musial, M Bajda, B Malawska - Current medicinal chemistry, 2007 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …
Molecular interactions of cholinesterases inhibitors using in silico methods: current status and future prospects
MTH Khan - New biotechnology, 2009 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a low amount of
acetylcholine (ACh) in hippocampus and cortex. Acetylcholinesterase (AChE) is one of the …
acetylcholine (ACh) in hippocampus and cortex. Acetylcholinesterase (AChE) is one of the …
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases
The multifactorial nature of Alzheimer's disease calls for the development of multitarget
agents addressing key pathogenic processes. To this end, by following a docking-assisted …
agents addressing key pathogenic processes. To this end, by following a docking-assisted …
Investigating 1, 2, 3, 4, 5, 6-hexahydroazepino [4, 3-b] indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for …
R Purgatorio, M de Candia, M Catto, A Carrieri… - European Journal of …, 2019 - Elsevier
Due to the role of butyrylcholinesterase (BChE) in acetylcholine hydrolysis in the late stages
of the Alzheimer's disease (AD), inhibitors of butyrylcholinesterase (BChE) have been …
of the Alzheimer's disease (AD), inhibitors of butyrylcholinesterase (BChE) have been …
[HTML][HTML] In-vitro and in-silico studies of annelated 1, 4, 7, 8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase
Based on previous finding showing 2, 3, 6, 11-tetrahydro-1H-azocino [4, 5-b] indole as
suitable scaffold of novel inhibitors of acetylcholinesterase (AChE), a main target of drugs for …
suitable scaffold of novel inhibitors of acetylcholinesterase (AChE), a main target of drugs for …
New azepino [4, 3-b] indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced …
M De Candia, G Zaetta, N Denora, D Tricarico… - European journal of …, 2017 - Elsevier
Abstract Several 6-substituted 3, 4, 5, 6-tetrahydroazepino [4, 3-b] indol-1 (2H)-one (THAI)
derivatives were synthesized and evaluated for their activity as cholinesterase (ChE) …
derivatives were synthesized and evaluated for their activity as cholinesterase (ChE) …
Radiosynthesis and whole‐body distribution in mice of a 18F‐labeled azepino[4,3‐b]indole‐1‐one derivative with multimodal activity for the treatment of Alzheimer's …
Abstract Recently, the azepino [4, 3‐b] indole‐1‐one derivative 1 showed in vitro nanomolar
inhibition against butyrylcholinesterase (BChE), the ChE isoform that plays a role in the …
inhibition against butyrylcholinesterase (BChE), the ChE isoform that plays a role in the …
Acetylcholinesterase inhibitory effect of lignans isolated fromSchizandra chinensis
TM Hung, MK Na, BS Min, TM Ngoc, IS Lee… - Archives of pharmacal …, 2007 - Springer
The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show
significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies …
significant inhibition of the activity of acetylcholinesterase enzyme (AChE). In further studies …
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid …
Targeting protein aggregation for the therapy of neurodegenerative diseases remains
elusive for medicinal chemists, despite a number of small molecules known to interfere in …
elusive for medicinal chemists, despite a number of small molecules known to interfere in …
Discovery of potent dual binding site acetylcholinesterase inhibitors via homo‐and heterodimerization of coumarin‐based moieties
Acetylcholinesterase (AChE) inhibitors still comprise the majority of the marketed drugs for
Alzheimer's disease (AD). The structural arrangement of the enzyme, which features a …
Alzheimer's disease (AD). The structural arrangement of the enzyme, which features a …