Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Pulmonary granulomas are widely considered the epicenters of the immune response to
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Recent animal …

CD4 T cells are essential for immunity to tuberculosis because they produce cytokines,
including interferon-γ. Whether CD4 T cells act as" helper" cells to promote optimal CD8 T …

Given the encouraging clinical results of both candidate subunit vaccines and revaccination
with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for …

A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) that we refer to as
'resisters'(RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite …

Tuberculosis (TB) is the leading cause of infectious death worldwide. Development of
improved TB vaccines that boost or replace BCG is a major global health goal. ID93+ GLA …

Granulomas are organized aggregates of macrophages, often with characteristic
morphological changes, and other immune cells. These evolutionarily ancient structures …

Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough
findings in both the basic immunology of Mycobacterium tuberculosis infection and the …