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[HTML][HTML] Amygdala circuit substrates for stress adaptation and adversity
Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …
significant adaptive value. A growing body of work across species demonstrates a critical …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
[HTML][HTML] Epigenetics of childhood trauma: Long term sequelae and potential for treatment
Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …
factors for neuropsychiatric diseases in adulthood. Recent advances in the field of …
[HTML][HTML] Sex-specific role for the long non-coding RNA LINC00473 in depression
Depression is a common disorder that affects women at twice the rate of men. Here, we
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …
[HTML][HTML] The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
Epigenetic programming by stress and glucocorticoids along the human lifespan
Psychosocial stress triggers a set of behavioral, neural, hormonal, and molecular responses
that can be a driving force for survival when adaptive and time-limited, but may also …
that can be a driving force for survival when adaptive and time-limited, but may also …
Hsp90 and FKBP51: complex regulators of psychiatric diseases
Mood disorders affect nearly a quarter of the world's population. Therefore, understanding
the molecular mechanisms underlying these conditions is of great importance. FK-506 …
the molecular mechanisms underlying these conditions is of great importance. FK-506 …
Unraveling the epigenetic landscape of depression: focus on early life stress
Depression is a devastating psychiatric disorder caused by a combination of genetic
predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular …
predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular …
The role of microRNAs in depression
Major depressive disorder (MDD) is a psychiatric disorder with increasing prevalence
worldwide. It is a leading cause of disability and suicide, severely affecting physical and …
worldwide. It is a leading cause of disability and suicide, severely affecting physical and …
Epigenetic changes associated with different types of stressors and suicide
Stress is associated with various epigenetic changes. Some stress-induced epigenetic
changes are highly dynamic, whereas others are associated with lasting marks on the …
changes are highly dynamic, whereas others are associated with lasting marks on the …