Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

The OPEP coarse-grained protein model has been applied to a wide range of applications
since its first release 15 years ago. The model, which combines energetic and structural …

Intrinsically disordered proteins (IDPs) play many biological roles in the human proteome
ranging from vesicular transport, signal transduction to neurodegenerative diseases. The Aβ …

Understanding the mechanisms underlying protein misfolding and aggregation has become
a central issue in biology and medicine. Compelling evidence show that the formation of …

Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Individual Alzheimer's disease (AD) patients have been shown to have structurally distinct
amyloid-β (Aβ) aggregates, including fibrils, in their brain. These findings suggest the …

The aggregation of β-amyloid peptides is a key event in the formative stages of Alzheimer's
disease. Promoting folding and inhibiting aggregation was reported as an effective strategy …

Increasing evidence supports the contribution of local inflammation to the development of
Alzheimer's disease (AD) pathology, although the precise mechanisms are not clear. In this …

Thioflavin T (ThT) assay is extensively used for studying fibrillation kinetics in vitro. However,
the differences in the time course of ThT fluorescence intensity and lifetime and other …

The human Islet Amyloid Polypeptide (hIAPP) is the major constituent of amyloid deposits in
pancreatic islets of type-II diabetes. IAPP is secreted together with insulin from the acidic …