NTRK fusion-positive cancers and TRK inhibitor therapy

E Cocco, M Scaltriti, A Drilon - Nature reviews Clinical oncology, 2018‏ - nature.com
N TRK gene fusions involving either NTRK1, NTRK2 or NTRK3 (encoding the neurotrophin
receptors TRKA, TRKB and TRKC, respectively) are oncogenic drivers of various adult and …

[HTML][HTML] NTRK gene fusions as novel targets of cancer therapy across multiple tumour types

A Amatu, A Sartore-Bianchi, S Siena - ESMO open, 2016‏ - Elsevier
The tropomyosin receptor kinase (Trk) receptor family comprises 3 transmembrane proteins
referred to as Trk A, B and C (TrkA, TrkB and TrkC) receptors that are encoded by the …

[HTML][HTML] Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer

A Amatu, A Sartore-Bianchi, K Bencardino… - Annals of …, 2019‏ - Elsevier
The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …

Targeting neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury

KM Keefe, IS Sheikh, GM Smith - International journal of molecular …, 2017‏ - mdpi.com
Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …

[HTML][HTML] Detection of tumor NTRK gene fusions to identify patients who may benefit from tyrosine kinase (TRK) inhibitor therapy

SJ Hsiao, A Zehir, AN Sireci, DL Aisner - The Journal of Molecular …, 2019‏ - Elsevier
Chromosomal rearrangements involving the NTRK1, NTRK2, and NTRK3 genes (NTRK
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …

The molecular basis of retinal ganglion cell death in glaucoma

M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012‏ - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Neurotrophic factors: an overview

SD Skaper - Neurotrophic Factors: Methods and Protocols, 2018‏ - Springer
The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …

Specificity of peripheral nerve regeneration: interactions at the axon level

I Allodi, E Udina, X Navarro - Progress in neurobiology, 2012‏ - Elsevier
Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

Gras** objects: the cortical mechanisms of visuomotor transformation

M Jeannerod, MA Arbib, G Rizzolatti, H Sakata - Trends in neurosciences, 1995‏ - Elsevier
Gras** requires coding of the object's intrinsic properties (size and shape), and the
transformation of these properties into a pattern of distal (finger and wrist) movements …

The neurotrophin family of neurotrophic factors: an overview

SD Skaper - Neurotrophic factors: Methods and protocols, 2012‏ - Springer
The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …