The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …

Glioblastoma (GBM) is one of the deadliest types of cancer and highly refractory to
chemoradiation and immunotherapy. One of the main reasons for this resistance to therapy …

Substitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive
subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide …

Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain stem tumor and the leading
cause of pediatric cancer-related death. To date, these tumors remain incurable …

Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of
maximal surgical tumor resection, accompanied by chemotherapy and radiotherapy …

Experience sculpts brain structure and function. Activity-dependent modulation of the
myelinated infrastructure of the nervous system has emerged as a dimension of adaptive …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors
lacking targeted therapies. They originate from interneuronal precursors; however …

Abstract H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas
(DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte …

Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated
epigenome and stalled differentiation. In contrast to the extensive datasets available on …