Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

The nucleolus is the most obvious and clearly differentiated nuclear sub-compartment. It is
where ribosome biogenesis takes place, but it is becoming clear that the nucleolus also has …

Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …

The nucleolus is the most obvious and clearly differentiated nuclear subcompartment. It is
where ribosome biogenesis takes place and has been the subject of research over many …

All living organisms need to duplicate their genetic information while protecting it from
unwanted mutations, which can lead to genetic disorders and cancer development …

In mammalian cells, active ribosomal genes produce the 18S, 5.8 S and 28S RNAs of
ribosomal particles. Transcription levels of these genes are very high throughout interphase …

Typically, only a fraction of the≥ 600 ribosomal RNA (rRNA) gene copies in human cells are
transcriptionally active. Expressed rRNA genes coalesce in specialized nuclear …

Nuclear organelles are viscous droplets, created by concentration-dependent condensation
and liquid–liquid phase separation of soluble proteins. Nuclear organelles have been …

Nucleoli are formed on the basis of ribosomal genes coding for RNAs of ribosomal particles,
but also include a great variety of other DNA regions. In this article, we discuss the …

In eukaryotes, DNA replication progresses through a finely orchestrated temporal and
spatial program. The 3D genome structure and nuclear architecture have recently emerged …