[HTML][HTML] Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate
During mouse embryonic development a mass of pluripotent epiblast tissue is transformed
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …
The multifunctional contribution of FGF signaling to cardiac development, homeostasis, disease and repair
The current focus on cardiovascular research reflects society's concerns regarding the
alarming incidence of cardiac-related diseases and mortality in the industrialized world and …
alarming incidence of cardiac-related diseases and mortality in the industrialized world and …
Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak
K Ivanovitch, P Soro-Barrio, P Chakravarty… - PLoS …, 2021 - journals.plos.org
The heart develops from 2 sources of mesoderm progenitors, the first and second heart field
(FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage …
(FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage …
GLI transcriptional repression is inert prior to Hedgehog pathway activation
The Hedgehog (HH) pathway regulates a spectrum of developmental processes through the
transcriptional mediation of GLI proteins. GLI repressors control tissue patterning by …
transcriptional mediation of GLI proteins. GLI repressors control tissue patterning by …
P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression
Q Li, Y Liu, J Wu, Z Zhu, J Fan, L Zhai, Z Wang, G Du… - Leukemia, 2024 - nature.com
Abstract Aberrations in the Hedgehog (Hh) signaling pathway are significantly prevailed in
various cancers, including B-cell lymphoma. A critical facet of Hh signal transduction …
various cancers, including B-cell lymphoma. A critical facet of Hh signal transduction …
Control of cardiomyocyte differentiation timing by intercellular signaling pathways
M Rowton, A Guzzetta, AB Rydeen… - Seminars in cell & …, 2021 - Elsevier
Abstract Congenital Heart Disease (CHD), malformations of the heart present at birth, is the
most common class of life-threatening birth defect (Hoffman (1995)[1], Gelb (2004)[2], Gelb …
most common class of life-threatening birth defect (Hoffman (1995)[1], Gelb (2004)[2], Gelb …
[HTML][HTML] 'Three signals-three body axes' as patterning principle in bilaterians
In vertebrates, the three orthogonal body axes, anteroposterior (AP), dorsoventral (DV) and
left-right (LR) are determined at gastrula and neurula stages by the Spemann-Mangold …
left-right (LR) are determined at gastrula and neurula stages by the Spemann-Mangold …
The molecular mechanisms of cardiac development and related diseases
Y Li, J Du, S Deng, B Liu, X **g, Y Yan, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Cardiac development is a complex and intricate process involving numerous molecular
signals and pathways. Researchers have explored cardiac development through a long …
signals and pathways. Researchers have explored cardiac development through a long …
[HTML][HTML] In vitro and in vivo models define a molecular signature reference for human embryonic notochordal cells
Understanding the emergence of human notochordal cells (NC) is essential for the
development of regenerative approaches. We present a comprehensive investigation into …
development of regenerative approaches. We present a comprehensive investigation into …
A quick and efficient method for the generation of immunomodulatory mesenchymal stromal cell from human induced pluripotent stem cell
Mesenchymal stromal cells (MSCs) have been widely investigated for their regenerative
capacity, anti-inflammatory properties and beneficial immunomodulatory effects across …
capacity, anti-inflammatory properties and beneficial immunomodulatory effects across …