Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …

Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

Background and Objectives New imaging techniques have advanced our ability to capture
thrombus characteristics and burden in real time. An improved understanding of …

Abstract Treatment of acute ischemic stroke has been recently improved with the
introduction of endovascular mechanical thrombectomy, a minimally invasive procedure …

Treatment of acute ischaemic stroke (AIS) focuses on rapid recanalisation of the occluded
artery. In recent years, advent of mechanical thrombectomy devices and new procedures …

An in silico trial simulates a disease and its corresponding therapies on a cohort of virtual
patients to support the development and evaluation of medical devices, drugs, and …

A State of the Art lecture titled “Thrombus Composition and Thrombolysis Resistance in
Stroke” was presented at the ISTH Congress in 2022. Intravenous thrombolysis (IVT) …

Thrombus composition and mechanical properties significantly impact the ease and
outcomes of thrombectomy procedures in patients with acute ischemic stroke. A wide …

Blood clots represent living materials composed of a polymer network and an abundance of
cells. They might fracture within the bulk material of the clot (cohesive fracture), at the …

Background Compositional and structural features of retrieved clots by thrombectomy can
provide insight into improving the endovascular treatment of ischemic stroke. Currently …