Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its
control over leukocyte-mediated immune responses. However, it is now recognized that …

Alzheimer's disease (AD) and prion disease are characterized neuropathologically by
extracellular deposits of Aβ and PrP amyloid fibrils, respectively. In both disorders, these …

The interest of scientists in the involvement of inflammation-related mechanisms in the
pathogenesis of Alzheimer's disease (AD) goes back to the work of one of the pioneers of …

Epidemiological studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) lower
the risk of develo** Alzheimer's disease (AD). Most NSAIDs act upon local inflammatory …

The pro‐inflammatory cytokines interleukin‐1β (IL‐1β), IL‐6, tumor necrosis factor‐α (TNF‐
α), and nitric oxide (NO) can be produced by activated glial cells and play a critical role in …

Although the CNS is an established immune-privileged site, it is under surveillance by the
immune system, particularly under pathological conditions. In the current study we examined …

The initial stages of Alzheimer's disease pathology in the neocortex show upregulation of
cell cycle proteins, adhesion and inflammation related factors, indicating the early …

Abstract α-secretase–mediated cleavage of amyloid precursor protein (APP) precludes
formation of neurotoxic amyloid-β (Aβ) peptides, and α-cleavage of cellular prion protein …

The amyloid plaques in Alzheimer's disease (AD) brains are co-localized with a broad
variety of inflammation-related proteins (complement factors, acute-phase proteins, pro …

The synaptic release of glutamate evokes in astrocytes periodic increases in [Ca2+] i, due to
the activation of metabotropic glutamate receptors (mGluRs). The frequency of these [Ca2+] i …