Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein–Barr virus and the gut–brain axis
K Hashimoto - Molecular Psychiatry, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …
Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions
K Hashimoto - Molecular Psychiatry, 2023 - nature.com
The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …
Central regulation of stress-evoked peripheral immune responses
Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …
associated with systemic inflammation. Recent studies have reported stress-induced …
[HTML][HTML] Arketamine, a new rapid-acting antidepressant: a historical review and future directions
The N-methyl-d-aspartate receptor (NMDAR) antagonist (R, S)-ketamine causes rapid onset
and sustained antidepressant actions in treatment-resistant patients with major depressive …
and sustained antidepressant actions in treatment-resistant patients with major depressive …
A role of splenic heme biosynthesis pathway in the persistent prophylactic actions of arketamine in lipopolysaccharide-treated mice
L Ma, L Wang, Y Qu, X Wan, K Hashimoto - Translational Psychiatry, 2023 - nature.com
Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine,
an (R)-enantiomer of ketamine, has persistent prophylactic actions in an inflammatory model …
an (R)-enantiomer of ketamine, has persistent prophylactic actions in an inflammatory model …
Arketamine for cognitive impairment in psychiatric disorders
K Hashimoto - European Archives of Psychiatry and Clinical …, 2023 - Springer
Cognitive impairment has been observed in patients with various psychiatric disorders,
including schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD) …
including schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD) …
A role of gut–microbiota–brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice
The α7 subtype of the nicotinic acetylcholine receptor (α7 nAChR: coded by Chrna7) is
known to regulate the cholinergic ascending anti-inflammatory pathway. We previously …
known to regulate the cholinergic ascending anti-inflammatory pathway. We previously …
[HTML][HTML] Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central
nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that …
nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that …
Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice
Abstract Classical psychedelics with 5-hydroxytryptamine-2A receptor (5-HT 2A R) agonism
have rapid antidepressant actions in patients with depression. However, there is an ongoing …
have rapid antidepressant actions in patients with depression. However, there is an ongoing …
A role of microRNA-149 in the prefrontal cortex for prophylactic actions of (R)-ketamine in inflammation model
L Ma, L Wang, L Chang, J Shan, Y Qu, X Wang… - …, 2022 - Elsevier
MicroRNAs (or miRNAs) are short, regulatory RNAs that act as post-transcriptional
repressors of gene expression. Recently, we reported that the nuclear factor of activated T …
repressors of gene expression. Recently, we reported that the nuclear factor of activated T …