Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

Signature Cytokines and Immune-Mediated Inflammatory Diseases The ability to block
specific cytokine pathways has revealed pathophysiological differences among autoimmune …

Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …

In chronic inflammatory diseases, such as asthma, rheumatoid arthritis, inflammatory bowel
disease, and psoriasis, several cytokines recruit activated immune and inflammatory cells to …

Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of
disability. It existed in early Native American populations several thousand years ago but …

Background Studies in animals and an open-label trial have suggested a role for antibodies
to tumor necrosis factor α, specifically chimeric monoclonal antibody cA2, in the treatment of …

Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that
cannot be cured and that has substantial personal, social, and economic costs. The long …

▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …

Background Neutralization of tumor necrosis factor α (TNF-α) for three to six months reduces
the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to …

TNF was originally described as a circulating factor that can cause necrosis of tumours, but
has since been identified as a key regulator of the inflammatory response. This review …