Structurally and functionally active synapses are essential for neurotransmission and for
maintaining normal synaptic and cognitive functions. Researchers have found that synaptic …

Synaptic dysfunction is thought to play important roles in the pathophysiology of many
neurological diseases, including Alzheimer's disease, Parkinson's disease, and …

Amyloid-β (Aβ) and hyperphosphorylated tau (p-tau) aggregates form the two discrete
pathologies of Alzheimer disease (AD), and oligomeric assemblies of each protein are …

The microtubule‐associated protein tau has primarily been associated with axonal location
and function; however, recent work shows tau release from neurons and suggests an …

Synaptic transfer of tau has long been hypothesized from the human pathology pattern and
has been demonstrated in vitro and in vivo, but the precise mechanisms remain unclear …

The pattern of neurodegeneration in Alzheimer's disease (AD) is very distinctive:
neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect …

Simufilam is a novel oral drug candidate in Phase 3 clinical trials for Alzheimer's disease
(AD) dementia. This small molecule binds an altered form of filamin A (FLNA) that occurs in …

Synaptic loss induced by beta-amyloid (Aβ) plays a critical role in the pathophysiology of
Alzheimer's disease (AD), but the mechanisms underlying this process remain unknown. In …

Apolipoprotein E (apoE) colocalizes with amyloid-β (Aβ) in Alzheimer disease (AD) plaques
and in synapses, and evidence suggests that direct interactions between apoE and Aβ are …

Abstract Background Apolipoprotein E4 (APOE4) is associated with a greater response to
neuroinflammation and the risk of develo** late-onset Alzheimer's disease (AD), but the …