Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Trained immunity as a molecular mechanism for BCG immunotherapy in bladder cancer

JH van Puffelen, ST Keating, E Oosterwijk… - Nature Reviews …, 2020 - nature.com
Intravesical BCG instillation is the gold-standard adjuvant immunotherapy for patients with
high-risk non-muscle-invasive bladder cancer. However, the precise mechanism of action by …

Macrophages in tuberculosis: friend or foe

E Guirado, LS Schlesinger, G Kaplan - Seminars in immunopathology, 2013 - Springer
Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …

The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis

R Kalscheuer, A Palacios, I Anso, J Cifuente… - Biochemical …, 2019 - portlandpress.com
Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …

[HTML][HTML] Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria

A Yonekawa, S Saijo, Y Hoshino, Y Miyake, E Ishikawa… - Immunity, 2014 - cell.com
Mycobacteria possess various immunomodulatory molecules on the cell wall. Mannose-
capped lipoarabinomannan (Man-LAM), a major lipoglycan of Mycobacterium tuberculosis …

Innate immune gene polymorphisms in tuberculosis

AK Azad, W Sadee, LS Schlesinger - Infection and immunity, 2012 - journals.asm.org
Tuberculosis (TB) is a leading cause worldwide of human mortality attributable to a single
infectious agent. Recent studies targeting candidate genes and “case-control” association …

Lipid-based mRNA vaccine delivery systems

P Midoux, C Pichon - Expert review of vaccines, 2015 - Taylor & Francis
Synthetic mRNAs can become biopharmaceutics allowing vaccination against cancer,
bacterial and virus infections. Clinical trials with direct administration of synthetic mRNAs …

Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host–pathogen interaction

AK Mishra, NN Driessen, BJ Appelmelk… - FEMS microbiology …, 2011 - academic.oup.com
Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?

SJ Sasindran, JB Torrelles - Frontiers in microbiology, 2011 - frontiersin.org
Tuberculosis is still a major health problem in the world. Initial interactions between
Mycobacterium tuberculosis and the host mark the pathway of infection and the subsequent …