Mycobacterium smegmatis: the vanguard of mycobacterial research

IL Sparks, KM Derbyshire, WR Jacobs Jr… - Journal of …, 2023 - Am Soc Microbiol
The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates

KS Wetzel, M Illouz, L Abad, HG Aull, DA Russell… - Nature …, 2023 - nature.com
Mycobacteriophages show promise as therapeutic agents for non-tuberculous
mycobacterium infections. However, little is known about phage recognition of …

Biotin-dependent cell envelope remodelling is required for Mycobacterium abscessus survival in lung infection

MR Sullivan, K McGowen, Q Liu, C Akusobi… - Nature …, 2023 - nature.com
Mycobacterium abscessus is an emerging pathogen causing lung infection predominantly in
patients with underlying structural abnormalities or lung disease and is resistant to most …

In vitro activity of cefoxitin, imipenem, meropenem, and ceftaroline in combination with vaborbactam against Mycobacterium abscessus

L Chen, E Shashkina, N Kurepina… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
Mycobacterium abscessus (MAB) infections pose a growing public health threat. Here, we
assessed the in vitro activity of the boronic acid-based β-lactamase inhibitor, vaborbactam …

Identification of drivers of mycobacterial resistance to peptidoglycan synthesis inhibitors

F Olivença, C Ferreira, A Nunes, C Silveiro… - Frontiers in …, 2022 - frontiersin.org
Beta-lactams have been excluded from tuberculosis therapy due to the intrinsic resistance of
Mycobacterium tuberculosis (Mtb) to this antibiotic class, usually attributed to a potent beta …

Mycobacterium abscessus DosRS two-component system controls a species-specific regulon required for adaptation to hypoxia

BS Simcox, BR Tomlinson, LN Shaw… - Frontiers in Cellular and …, 2023 - frontiersin.org
Mycobacterium abscessus (Mab), an emerging opportunistic pathogen, predominantly
infects individuals with underlying pulmonary diseases such as cystic fibrosis (CF). Current …

MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus

R Rodriguez, N Campbell-Kruger… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Mycobacterium abscessus (Mabs) is an emerging nontuberculosis mycobacterial (NTM)
pathogen responsible for a wide variety of respiratory and cutaneous infections that are …

Implementation of a mycobacterial CRISPRi platform in Mycobacterium abscessus and demonstration of the essentiality of ftsZMab

R Gupta, KH Rohde - Tuberculosis, 2023 - Elsevier
Mycobacterium abscessus (Mab) is a highly drug-resistant non-tuberculous mycobacterial
species that causes debilitating TB-like pulmonary infections. The lack of genetic tools has …

Chemical approaches to unraveling the biology of mycobacteria

P Finin, RMN Khan, S Oh, HIM Boshoff, CE Barry - Cell chemical biology, 2023 - cell.com
Mycobacterium tuberculosis (Mtb), perhaps more than any other organism, is intrinsically
appealing to chemical biologists. Not only does the cell envelope feature one of the most …

Durlobactam in combination with β-lactams to combat Mycobacterium abscessus

E Shin, KM Dousa, MA Taracila… - Antimicrobial Agents …, 2024 - journals.asm.org
Mycobacterium abscessus (Mab) presents significant clinical challenges. This study
evaluated the synergistic effects of a β-lactam and β-lactamase inhibitor combination against …