Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
Mechanisms of autoantibody-induced pathology
RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
[HTML][HTML] Desmosome structure, composition and function
D Garrod, M Chidgey - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist
mechanical stress because they adopt a strongly adhesive state in which they are said to be …
mechanical stress because they adopt a strongly adhesive state in which they are said to be …
Critical appraisal of different triggering pathways for the pathobiology of pemphigus vulgaris—A review.
Pemphigus vulgaris is an autoimmune blistering disease with an increased potential for
mortality. The epithelium is key in understanding the pathobiology as it is specialized to …
mortality. The epithelium is key in understanding the pathobiology as it is specialized to …
Mechanisms of disease: pemphigus and bullous pemphigoid
CM Hammers, JR Stanley - Annual Review of Pathology …, 2016 - annualreviews.org
Pemphigus and bullous pemphigoid are autoantibody-mediated blistering skin diseases. In
pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and …
pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and …
The desmosome
E Delva, DK Tucker… - Cold Spring Harbor …, 2009 - cshperspectives.cshlp.org
Desmosomes are intercellular junctions that tether intermediate filaments to the plasma
membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate …
membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate …
Pemphigus: a comprehensive review on pathogenesis, clinical presentation and novel therapeutic approaches
R Pollmann, T Schmidt, R Eming, M Hertl - Clinical reviews in allergy & …, 2018 - Springer
Pemphigus is a group of rare, potentially devastating autoimmune diseases of the skin and
mucous membranes with high morbidity and potentially lethal outcome. The major clinical …
mucous membranes with high morbidity and potentially lethal outcome. The major clinical …
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome
JR Stanley, M Amagai - New England Journal of Medicine, 2006 - Mass Medical Soc
Pemphigus, Bullous Impetigo, and the Staphylococcal Scalded-Skin Syndrome | New England
Journal of Medicine Skip to main content Access provided byMGH The New England Journal of …
Journal of Medicine Skip to main content Access provided byMGH The New England Journal of …
[HTML][HTML] Desmosomes: new perspectives on a classic
Desmosomes are highly specialized anchoring junctions that link intermediate filaments to
sites of intercellular adhesion, thus facilitating the formation of a supracellular scaffolding …
sites of intercellular adhesion, thus facilitating the formation of a supracellular scaffolding …
Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
S Kostenko, U Moens - Cellular and molecular life sciences, 2009 - Springer
The small heat shock protein Hsp27 or its murine homologue Hsp25 acts as an ATP-
independent chaperone in protein folding, but is also implicated in architecture of the …
independent chaperone in protein folding, but is also implicated in architecture of the …