Oocytes form before birth and remain viable for several decades before fertilization.
Although poor oocyte quality accounts for most female fertility problems, little is known about …

Simple Summary Cell-to-cell variation exists within a population of the same cell type due to
stochastic gene and protein expression and environmental factors. Studying such cellular …

Functional genomic strategies have become fundamental for annotating gene function and
regulatory networks. Here, we combined functional genomics with proteomics by quantifying …

Multiplexing strategies for large-scale proteomic analyses have become increasingly
prevalent, tandem mass tags (TMT) in particular. Here we used a large iPSC proteomic …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

Proteomics experiments commonly aim to estimate and detect differential abundance across
all expressed proteins. Within this experimental design, some of the most challenging …

System-wide quantitative analysis of ubiquitylomes has proven to be a valuable tool for
elucidating targets and mechanisms of the ubiquitin-driven signaling systems, as well as …

Targeted mass spectrometry assays for protein quantitation monitor peptide surrogates,
which are easily multiplexed to target many peptides in a single assay. However, these …

Blastocyst-derived embryonic stem cells (ESCs) and gonad-derived embryonic germ cells
(EGCs) represent two classic types of pluripotent cell lines, yet their molecular equivalence …

The composition of the tumor immune microenvironment (TIME) is considered a key
determinant of patients' response to immunotherapy. The mechanisms underlying TIME …