Therapeutic agent delivery across the blood–brain barrier using focused ultrasound

D McMahon, MA O'Reilly… - Annual Review of …, 2021 - annualreviews.org
Specialized features of vasculature in the central nervous system greatly limit therapeutic
treatment options for many neuropathologies. Focused ultrasound, in combination with …

Histotripsy: the next generation of high‐intensity focused ultrasound for focal prostate cancer therapy

TJ Dubinsky, TD Khokhlova… - … of Ultrasound in …, 2020 - Wiley Online Library
This article reviews the most current methods and technological aspects of high‐intensity
focused ultrasound (HIFU), which is termed histotripsy. The rationale for focal therapy for …

Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption

Y Yang, X Zhang, D Ye, R Laforest, J Williamson… - Scientific reports, 2019 - nature.com
Focused ultrasound combined with microbubble for blood-brain barrier disruption (FUS-
BBBD) is a promising technique for noninvasive and localized brain drug delivery. This …

Real-time passive acoustic map** with enhanced spatial resolution in neuronavigation-guided focused ultrasound for blood–brain barrier opening

S Bae, K Liu, AN Pouliopoulos, R Ji… - IEEE Transactions on …, 2023 - ieeexplore.ieee.org
Objective: Passive acoustic map** (PAM) provides the spatial information of acoustic
energy emitted from microbubbles during focused ultrasound (FUS), which can be used for …

Correlation between brain tissue damage and inertial cavitation dose quantified using passive cavitation imaging

S Xu, D Ye, L Wan, Y Shentu, Y Yue, M Wan… - Ultrasound in Medicine & …, 2019 - Elsevier
Focused ultrasound (FUS)-induced cavitation-mediated brain therapies have become
emerging therapeutic modalities for neurologic diseases. Cavitation monitoring is essential …

Real-time passive cavitation map** and B-mode fusion imaging via hybrid adaptive beamformer with modified diagnostic ultrasound platform

Y Zhu, G Zhang, Q Zhang, L Luo, B Ding, X Guo… - Ultrasonics, 2024 - Elsevier
The implementation of real-time, convenient and high-resolution passive cavitation imaging
(PCM) is crucial for ensuring the safety and effectiveness of ultrasound applications related …

Improved source localization in passive acoustic map** using delay-multiply-and-sum beamforming with virtually augmented aperture

CC Shen, YA Chen, HY Ku - Ultrasonics, 2023 - Elsevier
High-intensity focused ultrasound (HIFU) is a promising non-invasive treatment method
whose applications include tissue ablation, hemostasis, thrombolysis and blood–brain …

Real-time passive acoustic map** using sparse matrix multiplication

HAS Kamimura, SY Wu, J Grondin, R Ji… - IEEE transactions on …, 2020 - ieeexplore.ieee.org
Passive acoustic map** enables the spatiotemporal monitoring of cavitation with
circulating microbubbles during focused ultrasound (FUS)-mediated blood–brain barrier …

Dual-array passive acoustic map** for cavitation imaging with enhanced 2-D resolution

MD Gray, D Elbes, C Paverd, E Lyka… - IEEE Transactions …, 2020 - ieeexplore.ieee.org
Passive acoustic map** (PAM) techniques have been developed for the purposes of
detecting, localizing, and quantifying cavitation activity during therapeutic ultrasound …

3-D passive cavitation imaging using adaptive beamforming and matrix array transducer with random apodization

A Sivadon, F Varray, JC Béra… - IEEE Transactions on …, 2023 - ieeexplore.ieee.org
With the development of promising cavitation-based treatments, the interest in cavitation
monitoring with passive acoustic map** (PAM) is significantly increasing. While most of …