Genetics factors in major depression disease

M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders

DQ Beversdorf, HE Stevens, KL Jones - Current psychiatry reports, 2018 - Springer
Abstract Purpose of Review While genetic factors are a major etiological contributor to
autism spectrum disorder (ASD), evidence also supports a role for environmental factors …

A systematic review of genetic influence on psychological resilience

K Niitsu, MJ Rice, JF Houfek… - … research for nursing, 2019 - journals.sagepub.com
When exposed to adversity, some individuals are at an increased risk of posttraumatic stress
disorder, experiencing persistent biopsychosocial disturbances, whereas others adapt well …

Role of the 5-HTTLPR and SNP promoter polymorphisms on serotonin transporter gene expression: a closer look at genetic architecture and in vitro functional studies …

S Iurescia, D Seripa, M Rinaldi - Molecular neurobiology, 2016 - Springer
Abstract The serotonin (5-hydroxytriptamine (5-HT)) transporter (5-HTT) gene-linked
polymorphic region (5-HTTLPR) is a variable number tandem repeats (VNTR) located in the …

Precision medicine: does ethnicity information complement genotype-based prescribing decisions?

RR Shah, A Gaedigk - Therapeutic advances in drug safety, 2018 - journals.sagepub.com
Inter-ethnic differences in drug response are all too well known. These are underpinned by a
number of factors, including pharmacogenetic differences across various ethnic populations …

An integrative review of methylation at the serotonin transporter gene and its dialogue with environmental risk factors, psychopathology and 5-HTTLPR

H Palma-Gudiel, L Fañanás - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Abstract Gene—environment (G× E) interactions have largely been regarded as the root of
many complex disorders, including several psychiatric disorders. In this regard, it has been …

The role of serotonin in depression—A historical roundup and future directions

S Bremshey, J Groß, K Renken… - Journal of …, 2024 - Wiley Online Library
Depression is one of the most common psychiatric disorders worldwide, affecting
approximately 280 million people, with probably much higher unrecorded cases …

Maternal serotonin transporter genotype affects risk for ASD with exposure to prenatal stress

PM Hecht, M Hudson, SL Connors, MR Tilley… - Autism …, 2016 - Wiley Online Library
Stress exposure during gestation is implicated in several neuropsychiatric conditions,
including autism spectrum disorder (ASD). Previous research showed that prenatal stress …

Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy …

CC Chang, HA Chang, WH Fang, TC Chang… - Journal of Affective …, 2017 - Elsevier
Background A tri-allelic serotonin transporter promoter polymorphism (5-HTTLPR/rs25531)
more effectively determines the levels of transcriptional efficacy than that with the bi-allelic 5 …

Perinatal vs genetic programming of serotonin states associated with anxiety

SC Altieri, H Yang, HJ O'brien, HM Redwine… - …, 2015 - nature.com
Large numbers of women undergo antidepressant treatment during pregnancy; however,
long-term consequences for their offspring remain largely unknown. Rodents exposed to …