The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …

Cisplatin is a highly effective antitumor drug generally used in the treatment of solid
malignant tumors. However, cisplatin causes severe side effects such as bone marrow …

Cancer‐associated inflammation induces tumor progression to the metastatic stage, thus
indicating that a chemo‐anti‐inflammatory strategy is of interest for the management of …

Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …

A chemo-anti-inflammatory strategy is of interest for the treatment of aggressive cancers. The
platinum (IV) prodrug with non-steroidal anti-inflammatory drugs (NSAIDs) as axial ligands is …

Recently, artemisinin and derivatives have been revealed to possess encouraging antitumor
activity. Herein, we integrated the antitumor advantages of artesunate and platinum drugs to …

Cisplatin ototoxicity affects different individuals in a widely variable manner. These
variations are likely to be explained by genetic differences among those affected. It would be …

The isolated anatomical position and blood-labyrinth barrier hampers systemic drug delivery
to the mammalian inner ear. Intratympanic placement of drugs and permeation via the round …

Cyclooxygenase (COX) is an enzyme involved in tumorigenesis and is associated with
tumor cell resistance against platinum‐based antitumor drugs. Cisplatin analogues were …