Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

The synapse is the focus of experimental research and theory on the cellular mechanisms of
nervous system plasticity and learning, but recent research is expanding the consideration …

Many but not all cognitive abilities decline during ageing. Some even improve due to lifelong
experience. The critical capacities of attention and executive functions have been widely …

Working memory—the ability to maintain and manipulate information over a period of
seconds—is a core component of higher cognitive functions. The storage capacity of …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Diffusion tensor imaging (DTI) has been used widely to show structural brain changes
during both development and aging. Lifespan studies are valuable because they connect …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

The past several decades have witnessed unidimensional decline models of aging give way
to life-span developmental models that consider how specific processes and strategies …

Executive functions are high-level cognitive processes involving abilities such as working
memory/updating, set-shifting and inhibition. These complex cognitive functions are enabled …

Background: Inflammation is linked to cognitive decline in midlife, but the neural basis for
this link is unclear. One possibility is that inflammation associates with adverse changes in …