An overview of Nrf2 signaling pathway and its role in inflammation
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …
Alzheimer's disease, and many others, and the current state of available drugs prompted …
[HTML][HTML] Nrf2 signaling pathway: Pivotal roles in inflammation
Inflammation is the most common feature of many chronic diseases and complications, while
playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 …
playing critical roles in carcinogenesis. Several studies have demonstrated that Nrf2 …
[HTML][HTML] Endothelial dysfunction—a major mediator of diabetic vascular disease
The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …
vascular tone and structure. Endothelial cells produce a wide range of factors that also …
Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence
JC Wang, M Bennett - Circulation research, 2012 - Am Heart Assoc
Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …
A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
J Kim, YN Cha, YJ Surh - Mutation Research/Fundamental and Molecular …, 2010 - Elsevier
Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a key transcription factor that plays a
central role in cellular defense against oxidative and electrophilic insults by timely induction …
central role in cellular defense against oxidative and electrophilic insults by timely induction …
When NRF2 talks, who's listening?
Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental
and endogenous stresses and serves to render animals resistant to chemical …
and endogenous stresses and serves to render animals resistant to chemical …
Heme oxygenase-1, oxidation, inflammation, and atherosclerosis
JA Araujo, M Zhang, F Yin - Frontiers in pharmacology, 2012 - frontiersin.org
Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …
Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure
HJ Kim, ND Vaziri - American journal of physiology-renal …, 2010 - journals.physiology.org
Oxidative stress and inflammation are constant features and major mediators of progression
of chronic kidney disease (CKD). Nuclear factor erythroid-2-related factor-2 (Nrf2) confers …
of chronic kidney disease (CKD). Nuclear factor erythroid-2-related factor-2 (Nrf2) confers …
Redox roles of reactive oxygen species in cardiovascular diseases
F He, L Zuo - International journal of molecular sciences, 2015 - mdpi.com
Cardiovascular disease (CVD), a major cause of mortality in the world, has been extensively
studied over the past decade. However, the exact mechanism underlying its pathogenesis …
studied over the past decade. However, the exact mechanism underlying its pathogenesis …
Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans
JD Miller, Y Chu, RM Brooks, WE Richenbacher… - Journal of the American …, 2008 - jacc.org
Objectives: The aim of this study was to determine whether oxidative stress is increased in
calcified, stenotic aortic valves and to examine mechanisms that might contribute to …
calcified, stenotic aortic valves and to examine mechanisms that might contribute to …