Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens

YA Helmy, K Taha-Abdelaziz, HAEH Hawwas, S Ghosh… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …

Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

CW Hall, TF Mah - FEMS microbiology reviews, 2017 - academic.oup.com
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

Bacterial persisters and infection: past, present, and progressing

B Gollan, G Grabe, C Michaux… - Annual review of …, 2019 - annualreviews.org
Persisters are nongrowing, transiently antibiotic-tolerant bacteria within a clonal population
of otherwise susceptible cells. Their formation is triggered by environmental cues and …

Fighting bacterial persistence: current and emerging anti-persister strategies and therapeutics

V Defraine, M Fauvart, J Michiels - Drug Resistance Updates, 2018 - Elsevier
In addition to the well-known strategies of antibiotic resistance and biofilm formation,
bacterial populations possess an additional survival strategy to endure hostile environments …

Strategies to combat multidrug-resistant and persistent infectious diseases

O Pacios, L Blasco, I Bleriot, L Fernandez-Garcia… - Antibiotics, 2020 - mdpi.com
Antibiotic failure is one of the most worrying health problems worldwide. We are currently
facing an international crisis with several problematic facets: new antibiotics are no longer …

Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - journals.asm.org
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

The role of metabolism in bacterial persistence

SM Amato, CH Fazen, TC Henry, WWK Mok… - Frontiers in …, 2014 - frontiersin.org
Bacterial persisters are phenotypic variants with extraordinary tolerances toward antibiotics.
Persister survival has been attributed to inhibition of essential cell functions during antibiotic …

Novel approaches to combat bacterial biofilms

C Beloin, S Renard, JM Ghigo, D Lebeaux - Current opinion in …, 2014 - Elsevier
Highlights•Currently used antibiotics were developed to target planktonic bacteria.•Recent
discoveries on biofilm properties led to promising anti-biofilm strategies.•Biofilm inhibition …

Exploring an Efficient and Eco-Friendly Signaling Molecule and Its Quorum Quenching Ability for Controlling Microcystis Blooms

G Yan, L Fu, H Ming, C Chen… - Environmental Science & …, 2023 - ACS Publications
Globally, cyanobacterial blooms have become serious problems in eutrophic water. Most
previous studies have focused on environmental factors but have neglected the role of …