Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Type 2 diabetes mellitus (T2DM) is a complex disease in which both genetic and
environmental factors interact in determining impaired β-cell insulin secretion and peripheral …

The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …

Protein misfolding and aggregation are associated with more than twenty diseases, such as
neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may …

The amyloid-β (Aβ) peptides are key molecules in Alzheimer's disease (AD) pathology. They
interact with cellular membranes, and can bind metal ions outside the membrane. Certain …

Aβ oligomers are being investigated as cytotoxic agents in Alzheimer's disease (AD).
Because of their transient nature and conformational heterogeneity, the relationship …

Human islet amyloid polypeptide (hIAPP) is a highly amyloidogenic peptide found in
pancreatic islets of type-2 diabetes (T2D) patients. Under certain conditions, hIAPP is able to …

Abstract Islet Amyloid Polypeptide (IAPP), also known as amylin, is a 37-amino-acid peptide
hormone that is secreted by pancreatic islet β-cells. Amylin is complementary to insulin in …