Invited review: overview of new traits and phenoty** strategies in dairy cattle with a focus on functional traits

C Egger-Danner, JB Cole, JE Pryce, N Gengler… - Animal, 2015 - cambridge.org
For several decades, breeding goals in dairy cattle focussed on increased milk production.
However, many functional traits have negative genetic correlations with milk yield, and …

The cell biology of fertilization: Gamete attachment and fusion

KK Siu, VHB Serrão, A Ziyyat, JE Lee - Journal of Cell Biology, 2021 - rupress.org
Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse
to form a diploid zygote to initiate prenatal development. In mammals, fertilization involves …

Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm− oocyte fusion in mice

T Noda, Y Lu, Y Fujihara, S Oura… - Proceedings of the …, 2020 - National Acad Sciences
Sperm− oocyte membrane fusion is one of the most important events for fertilization. So far,
IZUMO1 and Fertilization Influencing Membrane Protein (FIMP) on the sperm membrane …

TMEM95 is a sperm membrane protein essential for mammalian fertilization

I Lamas-Toranzo, JG Hamze, E Bianchi… - elife, 2020 - elifesciences.org
The fusion of gamete membranes during fertilization is an essential process for sexual
reproduction. Despite its importance, only three proteins are known to be indispensable for …

Insertion/deletion within the KDM6A gene is significantly associated with litter size in goat

Y Cui, H Yan, K Wang, H Xu, X Zhang, H Zhu… - Frontiers in …, 2018 - frontiersin.org
A previous whole-genome association analysis identified lysine demethylase 6A (KDM6A),
which encodes a type of histone demethylase, as a candidate gene associated to goat …

The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization

Y Fujihara, S Herberg, A Blaha… - Proceedings of the …, 2021 - National Acad Sciences
Fertilization is the fundamental process that initiates the development of a new individual in
all sexually reproducing species. Despite its importance, our understanding of the molecular …

Molecular quantitative trait loci in reproductive tissues impact male fertility in cattle

XM Mapel, NK Kadri, AS Leonard, Q He… - nature …, 2024 - nature.com
Breeding bulls are well suited to investigate inherited variation in male fertility because they
are genotyped and their reproductive success is monitored through semen analyses and …

Evaluation of the accuracy of imputed sequence variant genotypes and their utility for causal variant detection in cattle

H Pausch, IM MacLeod, R Fries, R Emmerling… - Genetics Selection …, 2017 - Springer
Background The availability of dense genotypes and whole-genome sequence variants from
various sources offers the opportunity to compile large datasets consisting of tens of …

Human sperm TMEM95 binds eggs and facilitates membrane fusion

S Tang, Y Lu, WM Skinner, M Sanyal… - Proceedings of the …, 2022 - National Acad Sciences
Tmem95 encodes a sperm acrosomal membrane protein, whose knockout has a male-
specific sterility phenotype in mice. Tmem95 knockout murine sperm can bind to, but do not …

[HTML][HTML] Genome-wide map** and estimation of inbreeding depression of semen quality traits in a cattle population

M Ferenčaković, J Sölkner, M Kapš, I Curik - Journal of Dairy Science, 2017 - Elsevier
Inbreeding depression is known to affect quantitative traits such as male fertility and sperm
quality, but the genetic basis for these associations is poorly understood. Most studies have …