Conspectus Nuclear medicine leverages radioisotopes of a wide range of elements, a
significant portion of which are metals, for the diagnosis and treatment of disease. To …

Abstract Targeted Auger Therapy represents great potential for the therapy of diseases
which require a high degree of selectivity on the cellular level (eg for therapy of metastatic …

In the frame of “precision medicine”, the scandium radionuclides have recently received
considerable interest, providing personalised adjustment of radiation characteristics to …

Nuclear medicine leverages different types of radiometals for disease diagnosis and
treatment, but these applications usually require them to be stably chelated. Given the often …

Chelators are necessary in nuclear medicine imaging to direct an inorganic radionuclide, a
radiometal, to a desired target; unfortunately, there is no 'one-size-fits-all'chelator. As the …

Recently, promising results of the antitumor effects were observed in patients with metastatic
castration-resistant prostate cancer treated with 177Lu-labeled PSMA-ligands. Radionuclide …

Superior bifunctional chelating ligands, which can sequester both α-emitting radionuclides
(225Ac, 213Bi) and their diagnostic companions (155Tb, 111In), remain a formidable …

Herein, we present the syntheses and characterization of a new undecadendate chelator,
H4py4pa, and its bifunctional analog H4py4pa-phenyl-NCS, conjugated to the monoclonal …

A series of macrocyclic ligands were considered for the chelation of Pb2+: 1, 4, 7, 10-tetrakis
[2-(methylsulfanyl) ethyl]-1, 4, 7, 10-tetraazacyclododecane (DO4S), 1, 4, 7-tris [2 …

The nuclear decay characteristics of 225Ac (E α= 5–8 MeV, linear energy transfer (LET)=∼
100 keV/μm, t 1/2= 9.92 days) are well recognized as advantageous for the treatment of …