Combinatorial strategies in fluorescent probe development
The need for understanding essential recognition events in chemistry and biology has
directed considerable efforts toward the development of chemical probes. Fluorescent …
directed considerable efforts toward the development of chemical probes. Fluorescent …
Apparent activity in high-throughput screening: origins of compound-dependent assay interference
N Thorne, DS Auld, J Inglese - Current opinion in chemical biology, 2010 - Elsevier
Expansive compound collections made up of structurally heterogeneous chemicals, the
activities of which are largely undefined, present challenging problems for high-throughput …
activities of which are largely undefined, present challenging problems for high-throughput …
Rapid synthesis, screening, and identification of xanthone-and xanthene-based fluorophores using click chemistry
A panel of new fluorophores with emission wavelengths from blue to yellow regions using
the Cu (I)-catalyzed 1, 3-dipolar cycloaddition reaction of alkyne-functionalized xanthones …
the Cu (I)-catalyzed 1, 3-dipolar cycloaddition reaction of alkyne-functionalized xanthones …
Installation/modulation of the emission response via click reaction
We have demonstrated the installation of a fluorescence property into a nonfluorescent
precursor and modulation of an emission response of a pyrene fluorophore via click …
precursor and modulation of an emission response of a pyrene fluorophore via click …
Glucagon-secreting alpha cell selective two-photon fluorescent probe TP-α: for live pancreatic islet imaging
BK Agrawalla, Y Chandran, WH Phue… - Journal of the …, 2015 - ACS Publications
Two-photon (TP) microscopy has an advantage for live tissue imaging which allows a
deeper tissue penetration up to 1 mm comparing to one-photon (OP) microscopy. While …
deeper tissue penetration up to 1 mm comparing to one-photon (OP) microscopy. While …
Fluorescent biosensors for high throughput screening of protein kinase inhibitors
C Prével, M Pellerano, TNN Van… - Biotechnology …, 2014 - Wiley Online Library
High throughput screening assays aim to identify small molecules that interfere with protein
function, activity, or conformation, which can serve as effective tools for chemical biology …
function, activity, or conformation, which can serve as effective tools for chemical biology …
Diversity-oriented fluorescence library approaches for probe discovery and development
Diversity-oriented fluorescence library approaches have significantly accelerated the
development of new sensors. By making use of combinatorial chemistry and high …
development of new sensors. By making use of combinatorial chemistry and high …
Facets of click-mediated triazoles in decorating amino acids and peptides
Decorating biomolecular building blocks, such as amino acids, to afford desired and
tuneable photophysical/biophysical properties would allow chemical biologists to use them …
tuneable photophysical/biophysical properties would allow chemical biologists to use them …
Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging
J Miao, H Cui, J **, F Lai, H Wen, X Zhang… - Chemical …, 2015 - pubs.rsc.org
Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-
alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW∼ 205.19, λab∼ 350 nm, λem∼ 450 …
alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW∼ 205.19, λab∼ 350 nm, λem∼ 450 …
Combinatorial synthesis of new fluorescent scaffolds using click chemistry
F Cleemann, WL Kum-Cheung, P Karuso - Tetrahedron Letters, 2022 - Elsevier
Azides and acetylenes are bio-orthogonal functional groups that can be readily coupled
using copper (I)-or ruthenium (II)-catalyzed 1, 3-dipolar cycloaddition reactions. Using non …
using copper (I)-or ruthenium (II)-catalyzed 1, 3-dipolar cycloaddition reactions. Using non …