Pathogenesis of triple-negative breast cancer
F Derakhshan, JS Reis-Filho - Annual Review of Pathology …, 2022 - annualreviews.org
Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …
fundamentally different diseases with different histologic, genomic, and immunologic …
Genome protection by DNA polymerase θ
DNA polymerase θ (Pol θ) is a DNA repair enzyme widely conserved in animals and plants.
Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by …
Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by …
The role of artificial intelligence in deciphering diet–disease relationships: case studies
Modernization of society from a rural, hunter-gatherer setting into an urban and industrial
habitat, with the associated dietary changes, has led to an increased prevalence of …
habitat, with the associated dietary changes, has led to an increased prevalence of …
Mosaicism in human health and disease
Mosaicism refers to the occurrence of two or more genomes in an individual derived from a
single zygote. Germline mosaicism is a mutation that is limited to the gonads and can be …
single zygote. Germline mosaicism is a mutation that is limited to the gonads and can be …
Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations
CMS Tesileanu, WR Vallentgoed, M Sanson… - Acta …, 2021 - Springer
Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high
frequency in several tumour types. Even though these mutations are confined to distinct …
frequency in several tumour types. Even though these mutations are confined to distinct …
DNA repair, recombination, and damage signaling
DNA must be accurately copied and propagated from one cell division to the next, and from
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …
one generation to the next. To ensure the faithful transmission of the genome, a plethora of …
APOBEC3: friend or foe in human papillomavirus infection and oncogenesis?
Human papillomavirus (HPV) infection is a causative agent of multiple human cancers,
including cervical and head and neck cancers. In these HPV-positive tumors, somatic …
including cervical and head and neck cancers. In these HPV-positive tumors, somatic …
TP53 mutation infers a poor prognosis and is correlated to immunocytes infiltration in breast cancer
Z Zhang, R Hao, Q Guo, S Zhang… - Frontiers in Cell and …, 2021 - frontiersin.org
Background: This study aimed to investigate the TP53 mutation, its potential immune
features, its prognostic value, and its impact on immune infiltration in patients with breast …
features, its prognostic value, and its impact on immune infiltration in patients with breast …
Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma
SS Li, XH Zhai, HL Liu, TZ Liu, TY Cao… - … Hematology & Oncology, 2022 - Springer
Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-
Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal …
Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal …
Mutational signatures: From methods to mechanisms
Mutations are the driving force of evolution, yet they underlie many diseases, in particular,
cancer. They are thought to arise from a combination of stochastic errors in DNA processing …
cancer. They are thought to arise from a combination of stochastic errors in DNA processing …