Tumor-associated macrophages regulate PD-1/PD-L1 immunosuppression
Y Pu, Q Ji - Frontiers in immunology, 2022 - frontiersin.org
Anti-programmed cell death 1 (PD-1) or anti-PD-ligand (L) 1 drugs, as classic immune
checkpoint inhibitors, are considered promising treatment strategies for tumors. In clinical …
checkpoint inhibitors, are considered promising treatment strategies for tumors. In clinical …
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
X Shi, J Yang, S Deng, H Xu, D Wu, Q Zeng… - Journal of Hematology & …, 2022 - Springer
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …
Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory
Regulation of immune function continues to be one of the most well recognized extraskeletal
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …
actions of vitamin D. This stemmed initially from the discovery that antigen presenting cells …
[HTML][HTML] Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection
Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate,
a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted …
a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted …
TGF-β signaling networks in the tumor microenvironment
MKK Chan, JYF Chung, PCT Tang, ASW Chan, JYY Ho… - Cancer letters, 2022 - Elsevier
Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …
and pathology, especially in the progression of inflammatory diseases including cancer …
[HTML][HTML] TGFβ drives NK cell metabolic dysfunction in human metastatic breast cancer
Background Natural killer (NK) cells provide important immune protection from cancer and
are a key requirement for particular immunotherapies. There is accumulating evidence that …
are a key requirement for particular immunotherapies. There is accumulating evidence that …
The interplay between TGF-β signaling and cell metabolism
H Liu, YG Chen - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The transforming growth factor-β (TGF-β) signaling plays a critical role in the development
and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many …
and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many …
Lactate acidosis and simultaneous recruitment of TGF-β leads to alter plasticity of hypoxic cancer cells in tumor microenvironment
Lactate acidosis is often observed in the tumor microenvironment (TME) of solid tumors. This
is because glucose breaks down quickly via glycolysis, causing lactate acidity. Lactate is …
is because glucose breaks down quickly via glycolysis, causing lactate acidity. Lactate is …
TGFβ-directed therapeutics: 2020
BA Teicher - Pharmacology & therapeutics, 2021 - Elsevier
The transforming growth factor-beta (TGFβ) pathway is essential during embryo
development and in maintaining normal homeostasis. During malignancy, the TGFβ …
development and in maintaining normal homeostasis. During malignancy, the TGFβ …
Therapeutic targeting of TGF-β in cancer: hacking a master switch of immune suppression
Cancers may escape elimination by the host immune system by rewiring the tumour
microenvironment towards an immune suppressive state. Transforming growth factor-β (TGF …
microenvironment towards an immune suppressive state. Transforming growth factor-β (TGF …