The ATP–adenosine pathway functions as a key modulator of innate and adaptive immunity
within the tumour microenvironment. Consequently, multiple clinical strategies are being …

Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic
processes, including immunomodulation and cell proliferation. Tumors create an adenosine …

Background Immune checkpoint blockade resistance narrows the efficacy of cancer
immunotherapies, but the underlying mechanism remains elusive. Delineating the inherent …

While the understanding of the genomic aberrations that underpin chronic and acute
myeloid leukaemia (CML and AML) has allowed the development of therapies for these …

Acquired resistance represents a bottleneck for effective molecular targeted therapy in lung
cancer. Metabolic adaptation is a distinct hallmark of human lung cancer that might …

Cell-based immunotherapies can provide safe and effective treatments for various disorders
including autoimmunity, cancer, and excessive proinflammatory events in sepsis or viral …

Simple Summary Drug therapy is an important treatment for cancer patients; however, drug
resistance severely affects the survival time and quality of life of cancer patients. Oxidative …

Autophagy sustains cellular homeostasis and metabolism in numerous diseases. By
regulating cancer metabolism, both tumor and microenvironmental autophagy promote …

The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity
within the tumor microenvironment, and cancer immune evasion largely involves the …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …