Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders
Schizophrenia remains a major health burden, highlighting the need for new treatment
approaches. We consider the potential for targeting the trace amine (TA) system. We first …
approaches. We consider the potential for targeting the trace amine (TA) system. We first …
The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue
Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …
The endophenotype concept in psychiatry: etymology and strategic intentions
Endophenotypes, measurable components unseen by the unaided eye along the pathway
between disease and distal genotype, have emerged as an important concept in the study of …
between disease and distal genotype, have emerged as an important concept in the study of …
Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia
S Kapur - American journal of Psychiatry, 2003 - Am Psychiatric Assoc
OBJECTIVE: The clinical hallmark of schizophrenia is psychosis. The objective of this
overview is to link the neurobiology (brain), the phenomenological experience (mind), and …
overview is to link the neurobiology (brain), the phenomenological experience (mind), and …
Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity
Biological reactivity to psychological stressors comprises a complex, integrated, and highly
conserved repertoire of central neural and peripheral neuroendocrine responses designed …
conserved repertoire of central neural and peripheral neuroendocrine responses designed …
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates
gamma oscillations, rhythms that emerge during performance of cognitive tasks …
gamma oscillations, rhythms that emerge during performance of cognitive tasks …
[LIBRO][B] Psychophysiology: Human behavior and physiological response
JL Andreassi - 2010 - taylorfrancis.com
As new technology fuels the rapid growth of research in psychophysiology, it is essential that
those new to the field receive a comprehensive introduction. Psychophysiology: Human …
those new to the field receive a comprehensive introduction. Psychophysiology: Human …
Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
DL Braff, MA Geyer, NR Swerdlow - Psychopharmacology, 2001 - Springer
Rationale: Since the mid-1970s, cross-species translational studies of prepulse inhibition
(PPI) have increased at an astounding pace as the value of this neurobiologically …
(PPI) have increased at an astounding pace as the value of this neurobiologically …
NMDA receptor and schizophrenia: a brief history
JT Coyle - Schizophrenia bulletin, 2012 - academic.oup.com
Although glutamate was first hypothesized to be involved in the pathophysiology of
schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) …
schizophrenia in the 1980s, it was the demonstration that N-methyl-D-aspartate (NMDA) …
A method for evaluating dynamic functional network connectivity and task-modulation: application to schizophrenia
Objective In this paper, we develop a dynamic functional network connectivity (FNC)
analysis approach using correlations between windowed time-courses of different brain …
analysis approach using correlations between windowed time-courses of different brain …