Epidemiology of β-lactamase-producing pathogens
SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …
Past and present perspectives on β-lactamases
K Bush - Antimicrobial agents and chemotherapy, 2018 - Am Soc Microbiol
ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …
Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae
RM Martin, MA Bachman - Frontiers in cellular and infection …, 2018 - frontiersin.org
Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …
Interplay between β-lactamases and new β-lactamase inhibitors
Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …
Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance
Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting
humans and a major source for hospital infections associated with high morbidity and …
humans and a major source for hospital infections associated with high morbidity and …
The growing genetic and functional diversity of extended spectrum beta‐lactamases
The β‐lactams—a large class of diverse compounds—due to their excellent safety profile
and broad antimicrobial spectrum are considered to be the most widely used therapeutic …
and broad antimicrobial spectrum are considered to be the most widely used therapeutic …
Carbapenems: past, present, and future
In this review, we summarize the current “state of the art” of carbapenem antibiotics and their
role in our antimicrobial armamentarium. Among the β-lactams currently available …
role in our antimicrobial armamentarium. Among the β-lactams currently available …
Carbapenem resistance in Enterobacteriaceae: here is the storm!
The current worldwide emergence of resistance to the powerful antibiotic carbapenem in
Enterobacteriaceae constitutes an important growing public health threat. Sporadic …
Enterobacteriaceae constitutes an important growing public health threat. Sporadic …
Overcoming the rising incidence and evolving mechanisms of antibiotic resistance by novel drug delivery approaches–an overview
Antimicrobial resistance is a normal evolutionary process for microorganisms. Antibiotics
exerted accelerated selective pressure that hasten bacterial resistance through mutation …
exerted accelerated selective pressure that hasten bacterial resistance through mutation …
Updated functional classification of β-lactamases
K Bush, GA Jacoby - Antimicrobial agents and chemotherapy, 2010 - Am Soc Microbiol
Two classification schemes for β-lactamases are currently in use. The molecular
classification is based on the amino acid sequence and divides β-lactamases into class A …
classification is based on the amino acid sequence and divides β-lactamases into class A …