In this review article the history of leishmaniasis is discussed regarding the origin of the
genus Leishmania in the Mesozoic era and its subsequent geographical distribution, initial …

Progress in the diagnosis of leishmaniases depends on the development of effective
methods and the discovery of suitable biomarkers. We propose firstly an update …

Leishmania are eukaryotic parasites that have retained the ability to produce extracellular
vesicles (EVs) through evolution. To date, it has been unclear if different DNA entities could …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Next generation sequencing (NGS) combined with bioinformatics has successfully been
used in a vast array of analyses for infectious disease research of public health relevance …

Leishmania parasites cause a spectrum of clinical pathology in humans ranging from
disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference …

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS)
diversity set of 1.8 million compounds was screened against the three kinetoplastids most …

Abstract Background. Miltefosine (MIL), the only oral drug for visceral leishmaniasis (VL), is
currently the first-line therapy in the VL elimination program of the Indian subcontinent …

Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …